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Activated protein C (aPC), in a complex with protein S, inactivates procoagulant factors Va and VIIIa by proteolytic cleavage at specific arginine residues. 7,10,11 This serves to control …

Analysis is expanded to include promoter deletions for APC (1B and 1A). Clinically significant findings are confirmed by Sanger sequencing or qPCR. Results are reported using ACMG …

2023年6月23日 · APC resistance, also known as activated protein C resistance, refers to a condition in which there is reduced sensitivity of the clotting system to the anticoagulant effects …

Ratios less than 2.00 suggest APC resistance. This method uses factor V deficient plasma; therefore, APC resistance due to a nonfactor V mutation will not be detected. Extreme factor V …

Acceptable initial test to detect activated protein C resistance due to a factor V Leiden variant. Preferred test is APC Resistance Profile with Reflex to Factor V Leiden (0030192).

Protein C is activated to activated protein C (APC) via proteolytic cleavage by thrombin bound to thrombomodulin, an endothelial cell surface membrane protein. APC downregulates the …

The Activated Protein C Resistance (APCR) is a plasma based functional assay used to screen for the factor V Leiden mutation (F5:p.R506Q). Patients with factor V Leiden mutation have …

2023年6月23日 · APCR stands for Activated Protein C Resistance. It is a laboratory test used to assess the likelihood of an individual developing abnormal blood clotting, specifically venous …

The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. [1][2] …