APC-Min小鼠｜肠道肿瘤小鼠模型（结直肠癌模型） - 知乎
腺瘤息肉病大肠杆菌（APC）基因是一种肿瘤抑制基因，其编码的蛋白在 Wnt/β-catenin 信号通路 中起到关键的调控作用 [1]。 APC 蛋白能够拮抗 Wnt 信号通路，协助调控细胞迁移、黏附、 …
Mouse model of colorectal and intestinal cancer - Wikipedia
Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated, fed a modified diet, or challenged with chemicals to develop …
APCMin/+小鼠自发性结直肠癌癌前病变模型-
家族性腺瘤性息肉病(Familial Adenomatous Polyposis，FAP)是结直肠癌发生的癌前病变,患者结直肠部位多发成百上千个腺瘤性息肉，抑癌基因APC的突变是结直肠肿瘤的起始因素。
002020 - multiple intestinal neoplasia Strain Details
Homozygous C57BL/6J- Apc Min /J mice are not viable. The increased incidence of colorectal adenomas renders these mice a useful model of colon cancer. A small number of C57BL/6J- …
Apc mice: Models, modifiers and mutants - ScienceDirect
2008年7月25日 · A spectrum of Apc mutant mice has since been developed, each with defining characteristics, some more able to accurately model human polyposis and colon cancer. We …
The application of ApcMin/+ mouse model in colorectal tumor …
2019年3月18日 · ApcMin/+ mouse is an excellent animal model bearing multiple intestinal neoplasia, used to simulate human familial adenomatous polyposis and colorectal tumors. The …
APC-Min小鼠 - 知乎 - 知乎专栏
Apc-Min（Min:multiple intestinal neoplasia）突变小鼠特指Apc基因第850位氨基酸出现突变的C57BL/6J小鼠。Apc基因第850位氨基酸从Leu突变成终止密码子，导致翻译提前终止。 Apc …
The application of Apc Min/+ mouse model in colorectal tumor …
Purpose: Apc Min/+ mouse is an excellent animal model bearing multiple intestinal neoplasia, used to simulate human familial adenomatous polyposis and colorectal tumors. The key point …
More than two decades of Apc modeling in rodents - PMC
Mutation of tumor suppressor gene Adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular …
Characterization of Colorectal Cancer Development in Apc min/+ Mice
In this chapter, we will describe techniques for studying colon cancer development in Apcmin/+ mice on C57BL/6J (B6) background, focusing on the roles of environmental modifiers, …