APC controls Wnt-induced β-catenin destruction complex
2020年2月19日 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor …
Wnt/β-Catenin信号通路 - 知乎 - 知乎专栏
典型Wnt/β-catenin信号通路（Canonical Wnt/β-catenin pathway），此通路激活核内靶基因的表达； Wnt家族分泌蛋白、Frizzled家族跨膜受体蛋白Dishevelled（Dsh）、糖原合成激 …
Wnt β 连环蛋白通路 | Cell Signaling Technology
Wnt 配体是一种分泌型糖蛋白，可结合 Frizzled (卷曲）受体，然后与 LRP5/6 一起在细胞表面形成一个更大的复合体。 卷曲受体被 ZNRF3 和 RNF43 泛素化，二者的活性可通过 R-spondin 结 …
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Wnt信号通路是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。Wnt信号通路根据是否依赖于 β-catenin的转录活化， …
Mutant APC reshapes Wnt signaling plasma membrane …
2023年7月19日 · Here, we demonstrate the role of oncogenic APC in increasing plasma membrane free cholesterol and rigidity, thereby modulating Wnt signaling hubs. This results in …
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · In the cytoplasm, a “destruction complex” comprising adenomatous polyposis coli (APC), AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 protein (GSK3 protein) …
Apc, wnt signaling pathway regulator - Wikipedia
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion , …
APC controls Wnt-induced β-catenin destruction complex …
Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis …
APC controls Wnt-induced β-catenin destruction complex
2020年2月19日 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor …
Nature | Apc突变能驱动周围健康细胞的分化，驱动肿瘤形成 - 知乎
Apc−/−CM孵育的WT类器官显示出干性下降和分化增加的特征，这可以通过WNT和ISC的表达减少来证明。数据表明apc突变小鼠和人类细胞分泌因子，通过促进分化和减少干细胞数量，积极 …