2019年10月12日 · At a higher resolution, we identified distinct features of the actin cytoskeleton in the apical, basal, and lateral borders of the cells. These features could be used to identify segments of a nephron (the proximal tubule, thin and thick segments of Henle's loop, and distal tubule), the collecting duct system, the papillary ducts in the papilla ...

In the context of renal tubule physiology, the term basolateral membrane refers to the cell membrane which is oriented away from the lumen of the tubule, whereas the term apical or luminal membrane refers to the cell membrane which is oriented towards the lumen.

The apical plasma membrane faces the centrally located lumen, the lateral plasma membrane contacts adjacent cells, and the basal plasma membrane contacts the underlying extracellular matrix. Typically within the literature, the basal and lateral membranes are collectively referred to as basolateral membranes.

2022年4月19日 · Research has begun to reveal the dynamic interactions between polarity factors and how they contribute to polarity establishment and maintenance. Elucidating these mechanisms is essential to better...

2003年1月1日 · Surface membrane polarity is the key to nephron function: apical and basolateral membrane (BLM) domains that are structurally, biochemically, and physiologically unique enable cells to separate the glomerular .ltrate in the lumen from the interstitial compartment on the basal side of the epi­thelium.

Apical–Basal Polarization of Endocytic and Exocytic Membrane Trafficking Pathways. As the cell generates apical–basal polarity, the exocytic and endocytic pathways establish a complex interrelationship that regulates correct sorting of newly synthesized proteins to and between the apical and basolateral membrane domains.

We demonstrate that lumen formation and elongation require afadin, a nectin adaptor protein implicated in adherens junction formation. Mice that lack afadin in nephron precursors show evidence of Par3-expressing membrane microdomains, but fail to develop normal apical-basal polarity and generate a continuous lumen.

2019年10月1日 · Thin bundles of actin filaments line both the apical and basal membranes of the thin limbs. The single-layered epithelial lining covering the inner medullary region is also clearly ...

2011年10月1日 · Apico-basal membrane polarity facilitates the organization of receptors, ion transporters, channels, signal transduction complexes, and cytoskeletal proteins into functionally and structurally distinct domains of the cell surface that face different compartments.

At a high resolution, we identified actin cytoskeleton features of the apical, basal, and lateral borders of the epithelial cells to identify and distinguish between segments of a nephron (the proximal tubule, thin and thick segments of Henle's loop, and distal tubule) and the renal collecting duct system.