2019年4月11日 · A rapid confirmation of genetic diagnosis is mandatory and should be performed, if possible, on bone marrow (BM) samples.

2023年6月26日 · Acute promyelocytic leukemia is a distinguished subset of acute myeloid leukemia which is characterized by fusion gene transcript PML-RAR-alpha and high cure rates …

2021年6月30日 · Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), accounts for 10–15% of newly diagnosed AML cases. Approximately 800 patients are...

2018年7月26日 · Risk-adapted therapy allowed achieving remarkable cure rates in an international trial on childhood APL. Reduction of the anthracycline cumulative dose coupled …

2009年12月10日 · Acute promyelocytic leukemia is the first malignant disease highly curable with targeted therapy directed at a unique molecular abnormality. The characteristic bleeding …

Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia. The disease is characterized by a chromosomal abnormality involving translocation between chromosomes …

2024年5月21日 · What is APML? Acute promyelocytic leukaemia (APML) is a rare sub-type of acute myeloid leukaemia (AML) and is sometimes referred to as AML M31. APML accounts for …

2010年1月1日 · Bone marrow (BM) and/or peripheral blood (PB) smears from 349 patients in whom the diagnosis of APL was considered were assessed with the anti-PML antibody using …

After the initial therapeutic success reported in 1973 using an anthracycline (daunorubicin), 1 the management and outcome of acute promyelocytic leukemia (APL) has been revolutionized by …

Acute promyelocytic anaemia is characterized by the presence of atypical promyelocytes and a t (15;17) translocation, resulting in a PML-RARA fusion. It is often associated with pancytopenia …