In the field of molecular biology, apolipoprotein C is a family of four low molecular weight apolipoproteins, designated as C-I, C-II, C-III, and C-IV. These are surface components of chylomicrons, VLDL, and HDL. When an organism is in the fasting state, the C apolipoproteins are mainly associated with HDL.

Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons .

Apolipoproteins C (apoCs) are small polypeptides with molecular weights ranging from 6000 to 9000 d [1]. They mainly circulate in blood as components of chylomicrons, very low-density lipoproteins (VLDLs), and high-density lipoproteins (HDLs) and participate in the metabolism of these lipoprotein particles [1].

2024年1月15日 · 载脂蛋白C（apolipoprotein C, APOC）家族包括APOC1、APOC2、APOC3和APOC4四种亚型，APOC3最早于1969年提出，有99个氨基酸残基，成熟的形式缺乏信号肽的前20个氨基酸残基，成熟的APOC3由79个氨基酸构成，是一种较小的载脂蛋白。

Apolipoprotein C-III (apoC-III) is a key regulator of TG metabolism and hence circulating levels through several mechanisms including the inhibition of lipoprotein lipase activity and alterations in the affinity of apoC-III-containing lipoproteins for both the hepatic receptors involved in their removal and extracellular matrix in the arterial ...

Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during ...

Apolipoprotein C-II is a constituent of chylomicrons, very low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein (HDL). Apolipoprotein C-II contains 3 amphipathic α-helices. The lipid-binding domain of apoC-II is located in the N-terminal, whereas the C-terminal helix of apoC-II is responsible for the interaction with ...

Apolipoprotein (apo) C-II, whose two-dimensional structure is shown in the middle left, is the product of the APOC2 gene, which is part of the APOE–C1–C4–C2 (APO) gene cluster on the long arm of chromosome (Chr) 19.

2024年6月19日 · 载脂蛋白C Ⅱ（ApoC Ⅱ） 是冠状动脉粥样硬化性心脏病的保护因子。 ApoCⅡ作为LPL的辅助因子，可激活多种来源的LPL，维持脂蛋白的稳定性，保护血管内皮细胞。

2024年12月24日 · APOC3 (Apolipoprotein C3) is a Protein Coding gene. Diseases associated with APOC3 include Apolipoprotein C-Iii Deficiency and Lipodystrophy, Congenital Generalized, Type 1. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Visual phototransduction.