Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. [5] [6] As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism.

Apolipoprotein A-I (ApoA-I), the major protein component of high density lipoprotein (HDL), widely known for regulating cholesterol trafficking and for protecting against cardiovascular disease (CVD), may also modulate inflammatory and immune responses [1].

Apolipoprotein A1 (ApoA1) is the primary protein associated with high-density lipoprotein (HDL) particles, and plays a central role in reverse cholesterol transport. HDL cholesterol (HDL-C) and ApoA1 concentrations are inversely related to the risk for coronary artery disease (CAD).

2024年12月24日 · APOA1 (Apolipoprotein A1) is a Protein Coding gene. Diseases associated with APOA1 include Hypoalphalipoproteinemia, Primary, 2 and Amyloidosis, Hereditary Systemic 3 . Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Response to elevated platelet cytosolic Ca2+ .

Mutations in the APOA1 gene cause familial HDL deficiency, an inherited condition characterized by low levels of HDL in the blood and an elevated risk for early-onset cardiovascular disease, which often occurs before age 50. These mutations lead to an altered apoA-I protein.

2021年2月16日 · Purpose of the review: Apolipoprotein (APO) A1, the main apolipoprotein of plasma high-density lipoproteins (HDLs), has several well documented cardioprotective functions. A number of additional potentially beneficial functions of APOA1 have recently been identified.

2025年2月8日 · ApoA1 enhances resolution of allergen-induced airway inflammation through promoting recovery of damaged TJs in the bronchial epithelium. APOA1 is compact with four helical regions, amino acids 44-186, bundled together. Hereditary apolipoprotein A-I amyloidosis is characterized by slowly progressive renal disease.

Low levels of apolipoprotein A1 (ApoA1) confer increased risk of atherosclerotic cardiovascular disease. ApoA1 below 25 mg/dL may aid in the detection of a genetic disorder such as Tangier disease. ApoA1 is often interpreted as a ratio with apolipoprotein B (ApoB).

Apolipoprotein A-I (apo A-I) an indispensable component and a major structural protein of high-density lipoprotein (HDL), plays a vital role in reverse cholesterol transport and cellular cholesterol homeostasis since its identification.

2024年4月6日 · Cardiovascular events frequently recur after acute myocardial infarction, and low cholesterol efflux — a process mediated by apolipoprotein A1, which is the main protein in high-density...