Nature子刊综述：APOE家族与阿尔兹海默的相爱相杀 - 知乎
研究发现，APOE是65岁后发的迟发型 阿尔兹海默症 （AD）的主要风险因子，其中APOE*ε2对AD有保护作用，APOE*ε4会增强AD发病风险。 携带的APOE基因型比例也会影响患AD概 …
ApoE and Aβ in Alzheimer's disease: accidental encounters or
2014年2月19日 · Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE …
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4 …
Emerging data indicate that levels of soluble oAβ are increased with APOE4, providing a potential mechanism of APOE4 -induced AD risk. However, the pathway (s) by which apoE4 may …
Human APOE4 increases microglia reactivity at Aβ plaques in a …
2014年6月19日 · We report that APOE4 had an effect on Aβ plaques in the brain, and that E4FAD mice exhibited an increased density of reactive microglia within cortical plaque domains, …
Accumulation of intraneuronal Abeta correlates with ApoE4 …
In particular, the presence of one or two ApoE4 alleles strongly correlated with an increased accumulation of intraneuronal Abeta peptides. Given that ApoE4 is a major genetic risk factor …
APOE4-specific changes in Aβ accumulation in a new transgenic …
2012年12月7日 · APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different …
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP ... - Cell Press
2017年1月26日 · Human ApoE is expressed in three genetic isoforms, ApoE2, ApoE3, and ApoE4, which encode proteins that differ only in two residues. Strikingly, the ApoE4 allele is …
APOE4-specific Changes in Aβ Accumulation in a New Transgenic …
APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ …
APOE，或为阿尔茨海默病治疗的“绿色通道” - 知乎专栏
2022年12月23日 · 有证据表明与APOE3和APOE2相比，APOE4可以增加Aβ的产生，APOE4可能因为Aβ清除不足导致AD患病风险升高。 “策略说”：APOE与AD. 大多数的 AD治疗 都是靶 …
Three major effects of APOE ε4 on Aβ immunotherapy induced ARIA
2024年5月2日 · In this review we detail three hypothesized mechanisms by which APOE ε4 influences ARIA risk: (1) reduced cerebrovascular integrity, (2) increased neuroinflammation …
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