Stem cell and mesenchymal markers, including sex-determining region Y-box 2 (Sox2), were upregulated in aortic ECs of fat-fed ApoE-/-mice. Limiting Sox2 decreased marker expression and calcification in ApoE -/- aortas.

2020年5月12日 · The percentage of SOX2+ cells and TBR2+ cells at D12 and D18/19, as well as the percentage of SOX2+ and TBR2+ cells that showed immunostaining patterns for intracellular APOE were quantified using CellProfiler v3.1.9.

2022年3月28日 · We report that in aged human mesenchymal progenitor cells (MPCs), APOE accumulation is a driver for cellular senescence. By contrast, CRISPR–Cas9-mediated deletion of APOE endows human MPCs...

2021年8月28日 · In humans, the APOE gene encoding apolipoprotein E (apoE) exists as three polymorphic alleles (APOE2, APOE3, and APOE4), where APOE4 is the strongest genetic risk factor for AD [31, 36]. Furthermore, APOE genotype has been shown to be associated with the progression or poor clinical outcomes of other neurological or neurodegenerative diseases ...

2016年10月1日 · Stem cell and mesenchymal markers, including Sox2, are upregulated in aortic endothelial cells (ECs) of fat-fed ApoE −/− mice. Limiting Sox2 decreases the stem cell and mesenchymal markers and calcification in ApoE −/− aortas.

2021年9月14日 · Particularly, HGG-AM secretes interleukin (IL)-1β via the apolipoprotein E (ApoE)-mediated NLRP1 inflammasome, thereby promoting tumor progression. HGG-AM present extensive proliferation and infiltration to supplement the activated microglia pool. Notably, TGF-β1/TβRI depletion dramatically reduces HGG-AM density and suppresses tumor growth.

SOX7, 17, and 18 are essential in endothelial differentiation and SOX2 has emerged as an essential mediator of endothelial-mesenchymal transitions (EndMTs), a mechanism that enables the endothelium to contribute cells with abnormal cell differentiation to vascular disease such as calcific vasculopathy.

2024年10月1日 · In this study, we generated an iPSCs line sourced from a donor carrying APOE ɛ2, offering a valuable contract resource to APOE ɛ4 for the future study of Alzheimer's disease (AD). Peripheral blood mononuclear cells (PBMC) from an AD patient were reprogrammed into human induced pluripotent stem cells (hiPSCs) utilizing a non-integrating ...

We uncovered that pronethalol significantly reduced RBPJκ expression and its binding to Sox2 promoter 5, thereby preventing excess BMP/Notch signaling from inducing Sox2. In this study, we hypothesize that the beta-blockers suppress Sox2 also …

Immunocytochemistry showed that D12 and D18/19 cells expressed SRY-box transcription factor 2 (SOX2), a NSC marker, and T-Box Brain Protein 2 (TBR2), a neural progenitor cell (NPC) marker,...