C-terminal fragments of the amyloid precursor protein in ... - Nature
2017年5月30日 · In this study we investigated if APP-CTFs are detectable in CSF, characterized the major APP-CTF immunoreactive band, and determined whether the levels of this peptide …
CSF Biomarkers for Alzheimer's Disease Diagnosis - PMC
The processing of APP by α-secretase occurs via nonamyloidogenic pathway, and a reduced CSF level of sAPPα in AD patients has been reported . In contrast, APP processing first by β …
Soluble APP-α and APP-β in cerebrospinal fluid as potential ... - PubMed
Objectives: Concentrations of soluble amyloid precursor proteins-α (sAPPα) and -β (sAPPβ) in cerebrospinal fluid (CSF) may reflect the neuropathology of Alzheimer's disease (AD). We …
CSF proteomics identifies early changes in autosomal dominant …
2024年9月26日 · Autosomal dominant Alzheimer’s disease (ADAD) accounts for approximately 1% of all AD cases. 1 ADAD is characterized by the presence of autosomal dominant …
Amyloid precursor protein (APP) processing genes and …
2011年3月1日 · The aim of this exploratory investigation was to determine if genetic variation within amyloid precursor protein (APP) or its processing enzymes correlates with APP …
Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid …
2017年9月22日 · In this study, we re-assessed the utility of sAPPα and sAPPβ in CSF as diagnostic biomarkers of dementia disorders. We used a modified and sensitive detection …
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease ...
2024年1月9日 · In this study, we used these techniques and detected more than 3,000 proteins in the CSF in another independent cohort of 609 individuals to replicate and refine the existing …
Soluble APP-α and APP-β in cerebrospinal fluid as ... - Springer
2021年7月20日 · Concentrations of soluble amyloid precursor proteins-α (sAPPα) and -β (sAPPβ) in cerebrospinal fluid (CSF) may reflect the neuropathology of Alzheimer’s disease (AD).
Heteromers of amyloid precursor protein in cerebrospinal fluid
2015年1月8日 · Soluble fragments of the amyloid precursor protein (APP) generated by α- and β-secretases, sAPPα and sAPPβ, have been postulated as promising new cerebrospinal fluid …
C-terminal fragments of the amyloid precursor protein in cerebrospinal ...
2017年5月30日 · In this study we investigated if APP-CTFs are detectable in CSF, characterized the major APP-CTF immunoreactive band, and determined whether the levels of this peptide …