Amyloid-beta precursor protein - Wikipedia
APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the …
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · Here, we systematically review and update the vast state-of-the-art literature of Aβ science with evidence from basic research studies to human genetic and multi-modal …
Amyloid precursor protein (APP) and amyloid β (Aβ) interact …
Accumulation and aggregation of neurotoxic amyloid-β (Aβ) peptides generated via amyloidogenic processing of amyloid precursor protein (APP) is considered to play a central role in the …
An Overview of APP Processing Enzymes and Products - PMC
The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor protein (APP) has been at the center of Alzheimer’s disease (AD) research. While the basic …
Not just amyloid: physiological functions of the amyloid …
2017年3月31日 · Amyloid precursor protein (APP) has been heavily implicated in Alzheimer disease, but the physiological roles of APP and the related APP-like proteins (APLPs) remain …
Molecular Characteristics of Amyloid Precursor Protein (APP) …
Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are …
Amyloid Precursor Protein - an overview | ScienceDirect Topics
Amyloid precursor protein (APP) is a transmembrane protein that is synthesized in the endoplasmic reticulum and plays a major role in synaptic development, mineral transfer, …
Biology and pathophysiology of the amyloid precursor protein
2011年4月28日 · The amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …
APP processing in Alzheimer's disease - Molecular Brain
2011年1月7日 · Aβ is generated from β-amyloid precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase complex. Alternatively, APP can be …
APP Gene - GeneCards | A4 Protein | A4 Antibody
2024年12月9日 · APP (Amyloid Beta Precursor Protein) is a Protein Coding gene. Diseases associated with APP include Cerebral Amyloid Angiopathy, App-Related and Alzheimer …
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