Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.

Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability.

2016年3月1日 · 摘要: 肾脏集合管细胞通过水通道蛋白2（aquaporin-2，AQP2）调控水的重吸收进而调控机体的水代谢平衡。AQP2主要分布于集合管主细胞的管腔侧质膜及细胞内囊泡内，精氨酸加压素（arginine vasopressin，AVP）可刺激其由囊泡转移至质膜，这种AQP2的再分布过程被称 …

2012年10月1日 · This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2. Regarding the structure and function of AQP2, further structural analysis is necessary to understand the basic properties of individual channel function, for examples, such as possible regulation by gating.

2021年7月1日 · Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is essential for the maintenance of mammalian water homeostasis. The vasopressin V2 receptor (V2R), which is...

Aquaporin 2 (AQP2) plays an important, VP (vasopressin)-regulated role in water reabsorption by the kidney. The amount of AQP2 expressed at the surface of principal cells re...

2023年9月6日 · Here we describe the structural and functional characterization of three AQP2 mutations associated with recessive NDI: T125M and T126M, situated close to a glycosylation site and A147T in the...

The AQP2 gene provides instructions for making a protein called aquaporin 2. Learn about this gene and related health conditions.

In the kidney, vasopressin binds to the type 2 vasopressin receptor (V2R) and increases osmotic water transport through the regulation of the aquaporin-2 (AQP2) water channel localized in the kidney connecting tubules and collecting ducts 1, 2. V2R is a G-protein-coupled receptor (GPCR) localized at the basolateral plasma membrane of the ...

1996年3月1日 · Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct. AQP-2 is selectively permeable to water molecule and is translocated between the apical membrane and subapical endosomes in response to vasopressin.