Oral leukoplakia and oral submucous fibrosis are 2 main oral potentially malignant disorders caused by areca nut chewing that can progress to oral cancer with continued use. Ex-chewers seem to demonstrate lower risks than current chewers, but the impact of areca nut cessation on oral cancer risk has not been scientifically evaluated on the ...

Areca nut chewing is one of the major risk factors for oral cancer, with large-magnitude risks reported in studies comparing betel quid chewers and never users, and it has been evaluated as a group 1 carcinogen by the International Agency for Research on Cancer.

2025年1月10日 · However, in recent years, with the escalating incidence of oral cancer, scientists have delved deeper into the hazards of areca nut and discovered that chemical substances in areca nut, such...

Consumption or chewing of areca nut (AN), the seed (endosperm) found in the fruit of the Areca catechu tree, is a cultural habit in the tropical countries of South Asia, the Asian Pacific region, and some parts of East Africa [1]. In 2004, AN was classified as a group 1 human carcinogen by the International Agency for Research on Cancer [2].

2002年4月4日 · From the medical point of view, the most important consideration is the relation between areca nut use and the development of mouth cancer (oral squamous cell carcinoma) and its precursors leukoplakia and submucous fibrosis. 3,4

2022年6月24日 · Areca nut chewing is one of the major risk factors for oral cancer, with large-magnitude risks reported in studies comparing betel quid chewers and never-users, and it has been evaluated as a...

2019年7月8日 · Consistently, oral cancer patients with habitual chewing areca nut exhibit more aggressive phenotypes, including resistance to chemo-radiotherapy. In this review, we comprehensively discuss and concisely summarize the up-to-date molecular and cellular mechanisms by which areca nuts contribute to malignant transformation.

2024年8月20日 · Our study provides novel mechanisms for areca nut-induced oral carcinogenesis, demonstrating that areca nut promotes M2 macrophage differentiation and secretion of oncogenic cytokines that critically activate malignant transformation of oral premalignant cells.

Epidemiological studies consistently reveal a significant correlation between areca nut use and the incidence of oral cancer, emphasizing the need for targeted preventive measures. The complex interplay of areca nut's bioactive compounds, particularly arecoline, with cellular processes, contributes to the initiation and progression of oral ...

The oral cancer patients who habitually chewed areca nuts exhibited more aggressive cancer phenotypes, with higher rates of cancer metastasis, recurrence, and poor patient survival. Thus, areca nuts contribute to oral carcinogenesis via multifaceted mechanisms.