2024年12月24日 · ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include Urea Cycle Disorder and Argininemia . Among its related pathways are superpathway of L-citrulline metabolism and Metabolism of proteins .

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2021年3月5日 · Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for...

Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration.

2019年4月8日 · Here we identify arginase 2 (Arg2) as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose...

At least two isoforms of mammalian Arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney.

2025年1月4日 · Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

Arg2 facilitates urea cycle function, and impaired urea cycle incites mitochondrial dysfunction via insufficient NADH production through the TCA cycle. We thus tested the hypothesis that urea cycle impairment represents a provocative event in the pathogenesis of hepatic steatosis and insulin resistance.

2019年7月9日 · 精氨酸酶存在两种亚型（ARG1和ARG2），催化相同的生化反应，但在亚细胞定位，表达和调节方面不同。 ARG1是一种胞质蛋白，而ARG2主要定位于线粒体。 高精氨酸酶水平，ARG1或ARG2，存在于多种癌症类型，包括乳腺癌、NSCLC、头颈部鳞状细胞癌、肾癌、结肠直肠癌、皮肤癌和宫颈癌。 精氨酸酶主要由在TME中高度富集的髓样抑制细胞（MDSCs）产生，并且表达ARG1的MDSCs在改变癌症患者的T细胞应答中的发挥作用。 尽管如此，越来越多 …

2022年10月8日 · There are two isoforms of arginase: arginase 1 (ARG1), which is expressed in the cytosol, and arginase 2 (ARG2), which is mainly located in the mitochondria. Although there are approximately 60%...