2021年3月5日 · Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for...

2023年12月26日 · m2巨噬细胞的主要标记是 cd163 和cd206。此外，精氨酸酶1（arg1）和dectin-1也是用于鉴定m2巨噬细胞的理想表型指标。 研究还显示，fizz1、ym1和ly6c 也可以用作与m1或m2巨噬细胞亚群相关的表面标记。

2023年9月12日 · We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response. Here, we investigate the therapeutic potential of Arg2 enhancement via target site blockers (TSBs) in human macrophages.

2021年10月27日 · The M1 killer type response and the M2 repair type response are best known, and are two extreme examples. Among other markers, inducible nitric oxide synthase and type-I arginase (Arg-I), the enzymes that are involved in l -arginine/nitric oxide (NO) metabolism, are associated with the M1 and M2 phenotype, respectively, and therefore widely ...

Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration.

Our findings of higher Arg1 and blunted induction of Arg2 in the iPLA 2 β −/−, relative to WT macrophages support the possibility that Arg2 is a proinflammatory marker under classical activation conditions, as might exist in an in vivo inflammatory milieu such as T1D.

2022年10月8日 · ARG1 promotes M2 anti-inflammation response through blocking NO production from iNOS, but ARG2 induces pro-inflammatory cytokine production (TNF-α, IL-6, and MCP-1) in M1 via mitochondrial ROS...

2023年6月14日 · 尽管 Arg1 基因表达是可塑的，并且在 LPS + IFNγ 刺激后仍可被 IL-4 诱导（图 1B），但与 M2 细胞相比，M1→M2 巨噬细胞显示出明显较少的 IL-4 诱导的精氨酸酶功能（图 1D）。 同样，LPS + IFNγ 预处理损害了 IL-10 引发的 M2 样表型的诱导。 接下来，作者通过比较 LPS + IFNγ 诱导的 M2→M1 反应与正常 M1 细胞（红色）的反应，研究了 M2 巨噬细胞产生炎症反应的能力。 作者发现，与第一次刺激无关，LPS + IFNγ 在 M2→M1 和 M1 细胞中有效诱导 …

Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration.

2021年3月5日 · Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and …