We propose that l-arginine can interrupt the vicious cycle that initiates and maintains low NO in hypertension by increasing the formation of NO. 1. l-Arginine is the substrate for vascular nitric oxide (NO) formation. Under normal physiological conditions, intracellular l-arginine levels far exceed the K (m) of NO synthase for l-arginine.

As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of protein but also as an essential substrate for the synthesis of nitric oxide (NO), creatine, polyamines, homoarginine, and agmatine in mammals (including humans). NO …

Some cell types take up and/or synthesize arginine in support of nitric oxide (NO) synthesis (Fig. 1). In this cycle, arginine is converted to citrulline by nitric oxide synthases (NOS) (Förstermann and Sessa, 2012), producing NO. NO is an important regulator of vascular tone (Levine et al, 2012). Citrulline can be recycled back to arginine ...

Increasing the arginine availability by arginine therapy or arginase inhibition was therefore proposed as a potential therapy to treat hypertension. Recent studies in septic patients and transgenic mice models found that inadequate de novo arginine production from …

2006年9月1日 · Nitric oxide (NO) is synthesized from l -arginine by NO synthase in virtually all cell types. Emerging evidence shows that NO regulates the metabolism of glucose, fatty acids and amino acids in mammals. As an oxidant, pathological levels of NO inhibit nearly all enzyme-catalyzed reactions through protein oxidation.

2004年10月1日 · L-Arginine is the biological precursor of nitric oxide (NO), which serves as an important signal and effector molecule in animals. This review summarizes some structure-function aspects of the mammalian nitric oxide synthases, which are enzymes that catalyze the oxidation of L-arginine to NO and L-citrulline.

L-Arg is the precursor for the synthesis of nitric oxide (NO); a key signaling molecule via NO synthase (NOS). Endogenous NOS inhibitors such as asymmetric-dimethyl-L-Arg inhibit NO synthesis in vivo by competing with L-Arg at the active site of NOS.

NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme nitric oxide synthase or synthetase (NOS), and the effects of NO are mainly mediated by 3,'5' -cyclic guanylate or cyclic GMP.

2009年2月25日 · l-Arginine was discovered as a naturally occurring amino acid more than a century ago. 1 The more recent discovery that nitric oxide (NO), 2 derived from l-arginine, is a major endothelium-derived relaxing factor shifted the focus of interest in l-arginine towards its potential role in cardiovascular control.

2024年12月1日 · l-arginine generates nitric oxide (NO), a vasodilator that increases blood flow to the brain, providing oxygen and nutrients. It also has anti-inflammatory and anti-apoptotic properties, protecting neurons from oxidative stress and excitotoxicity [ 56 ].