ROS-Induced Activation of DNA Damage Responses Drives
2019年1月28日 · Reactive oxygen species (ROS) may be one of the main causal factors of age-related cochlear cell degeneration. We examined whether ROS-induced DNA damage …
Loss of synaptic ribbons is an early cause in ROS-induced acquired ...
2023年10月1日 · Synaptic ribbons are a promising target for novel therapeutics for ROS-induced SNHL. Considerable evidence of reactive oxygen species (ROS) involvement in cochlear hair …
ROS-Induced Activation of DNA Damage Responses Drives ... - PubMed
We examined whether ROS-induced DNA damage response drives cochlear cell senescence and contributes to ARHL from the cellular up to the system level.
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell …
2022年10月20日 · Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and …
Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death ...
In the CBA/J experimental model of ARHL, ROS increased alongside the decrease in SOD2 at 18 months of age . This suggests that SNHL may be driven by oxidative stress-related DNA and …
Down-regulation of Cav1.3 in auditory pathway promotes age …
Presbycusis or age-related hearing losses (ARHL) is the most common cause of hearing loss [1, 2]. Overall, 10% of population experience hearing loss which is sufficient to influence …
We examined whether ROS-induced DNA damage response drives cochlear cell senescence and contributes to ARHL from the cellular up to the system level.
氧化应激在年龄相关性耳聋中的作用研究进展 - 搜狐
2019年12月2日 · ARHL临床上又称老年性聋（Presbycusis），发病从高频听力损失开始，逐渐累积低频听力，以听觉灵敏度降低为主，伴随着言语识别力的下降，是双耳对称出现并缓慢发展 …
Recognition and Control of the Progression of Age-Related …
2013年12月1日 · Accumulating evidence 15, 16 from genetic and electrophysiological studies postulates that reactive oxygen species (ROS)-related mitochondrial (mtDNA mutations and …
ROS-Induced Activation of DNA Damage Responses Drives …
Reactive oxygen species (ROS) may be one of the main causal factors of age-related cochlear cell degeneration. We examined whether ROS-induced DNA damage response drives …