The Duality of Arsenic Metabolism: Impact on Human Health
2023年1月20日 · In this review, we approach the topic of arsenic metabolism from both perspectives to create a complete picture of its potential role in the mitigation or aggravation of various arsenic-related pathologies. Keywords: arsenic; detoxification; metabolism; methylation; speciation; toxicity.
Arsenic Metabolism and Toxicity in Humans and Animals: Racial …
2018年11月12日 · Susceptibility to the toxic effects of arsenic is influenced by an organism’s capacity for arsenic metabolism. To fully understand this potential, the pathways and properties of arsenic species (trivalent, pentavalent, methylated, or thiolated) as well as glutathione conjugates in the animal or human body must be assessed.
Metabolism of arsenic and its toxicological relevance
2012年7月19日 · The present review discusses both the metabolism of arsenic and the toxicity of arsenic metabolites. Arsenic is a worldwide environmental pollutant and a human carcinogen. It is well recognized that the toxicity of arsenicals largely depends on the oxidore
Arsenic and human health effects: A review - ScienceDirect
2015年11月1日 · In this review, we outline the effects of arsenic on the human body with a main focus on assorted organ systems with respective disease conditions. Additionally, underlying mechanisms of disease development in each organ system …
The Duality of Arsenic Metabolism: Impact on Human Health
Arsenic is a naturally occurring hazardous element that is environmentally ubiquitous in various chemical forms. Upon exposure, the human body initiates an elimination pathway of progressive methylation into relatively less bioreactive and more easily …
Arsenic in Tissues, Organs, and Cells | SpringerLink
In human, arsenic metabolism is characterized by two main types of reactions (Jomova et al. 2011; Nicolis et al. 2009; Rossman and Klein 2011): (1) reduction reactions of pentavalent to trivalent arsenic and (2) oxidative methylation reactions in which trivalent forms of arsenic are sequentially methylated to form methylated products using S ...
Host-microbiota interplay in arsenic metabolism: Implications on …
3 天之前 · The metabolism of arsenic in the human system is a highly intricate process involving both inorganic and organic forms of the metalloid [27] (Fig.1A). Inorganic arsenic is predominantly absorbed through transporters in the gastrointestinal tract, and its biological half-life is approximately 10 hours [34].
Arsenic inorganic exposure, metabolism, genetic biomarkers and …
2024年7月1日 · This work describes the mechanisms of environmental exposure to arsenic, molecular regulatory factors involved in its metabolism, genetic polymorphisms affecting individual susceptibility and the toxic effects of arsenic on human …
ARSENIC: A Review on Exposure Pathways, Accumulation, …
This review deals with exposure pathways of arsenic (As), as well as its transfer and uptake processes from its source to the human body.
An Overview of Arsenic Metabolism and Toxicity - PubMed
Here, we provide an overview of current models for the biological methylation of arsenicals. This information provides a context for understanding the chemical, biochemical, and genetic approaches to elucidation of the formation and function of metahylated arsenicals which are presented in the following manuscripts.