The current first-line treatments for uncomplicated malaria recommended by the National Malaria Control Programme in Mali are artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ). From 2015 to 2016, an in vivo study was carried out to ...

Traitement en 1ère intention de l’accès palustre non compliqué. ƒTraitement de relais, après la thérapie par voie parentérale, de l’accès palustre grave.

2009年6月8日 · Patients suffering from uncomplicated P. falciparum malaria were randomized to receive ASAQ orally once daily (ASAQ1), ASAQ twice daily (ASAQ2) or AL twice daily (AL) for three days. The primary outcome was PCR-corrected parasitological cure …

The dispersible, fixed-dose combination of artesunate and amodiaquine (ASAQ) requires only one dose per day for three days, reducing the “pill burden” for both adults and children. It is also easier to administer to infants and young children because it dissolves in water.

Meta-analysis on PCR adjusted day 28 total treatment success indicates ASAQ is as efficacious as ALU and DHP in Sub-Saharan Africa. ASAQ has shown the highest PCR unadjusted efficacy than both ALU and DHP (94 vs 89 and 91 respectively).

Ne pas administrer en cas de réaction sévère lors d’un traitement antérieur à l’amodiaquine (p. ex. réaction d’hypersensibilité, hépatite, leucopénie, agranulocytose). Ne pas administrer chez les patients sous éfavirenz. Peut provoquer : troubles digestifs, prurit, somnolence ou insomnie, toux.

2012年5月3日 · Artesunate and amodiaquine hydrochloride in bilayer tablets were determined by micellar electrokinetic capillary chromatography (MEKC). Analytes were extracted from tablets by sonication with a solvent mixture phosphate buffer pH 7.0-acetonitrile containing benzoic acid as internal standard.

May cause: gastrointestinal disturbances, pruritus, somnolence or insomnia, cough. If the patient vomits within 30 minutes after administration, re-administer the full dose. If the patient vomits between 30 minutes and 1 hour after administration, re-administer half of the dose.

2022年3月10日 · ASAQ has shown the highest PCR unadjusted efficacy than both ALU and DHP (94 vs 89 and 91 respectively). ASAQ has retained high efficacy possibly due to its limited use owing to clinicians preferring to prescribe ALU over ASAQ avoiding high risk of neurological side effects associated with ASAQ.

2014年12月1日 · The safety and efficacy of the two most widely used fixed-dose artemisinin-based combination therapies (ACT), artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) are well established for single episodes of uncomplicated Plasmodium falciparum malaria, but the effects of repeated, long-term use are not well documented.