The African swine fever virus gene MGF_360-4L inhibits interferon ...
2025年2月25日 · In this study, we identified a virulence gene of ASFV, MGF_360-4L, that targets and recruits the selective autophagy receptor p62 to mediate the degradation of the dsRNA …
Structure of the recombinant RNA polymerase from African Swine …
2024年2月21日 · Here, we present methods to produce recombinant ASFV RNA polymerase, functional assays to screen for inhibitors, and high-resolution cryo-electron microscopy …
A novel TLR3 inhibitor encoded by African swine fever virus (ASFV)
African swine fever virus (ASFV) encodes proteins that manipulate important host antiviral mechanisms. Bioinformatic analysis of the ASFV genome revealed ORF I329L, a gene without …
J Virol. | OAS1通过募集TRIM21降解病毒主要衣壳蛋白来抑制ASFV …
2024年6月6日 · 研究报告表明，ASFV基因组中富含AT的区域可以通过Pol-III-RIG-I轴介导dsDNA到dsRNA的转变来激活先天抗病毒反应。 OAS1可以识别dsRNA产生OAS，从而激活 …
OAS1 suppresses African swine fever virus replication by recruiting ...
2023年10月10日 · Overexpression of OAS1 can promote the activation of the JAK-STAT pathway and enhance phosphorylation of STAT1 and STAT2, thus promoting innate immune responses …
The A137R Protein of African Swine Fever Virus Inhibits Type I ...
2022年4月12日 · ASFV dsDNA can be sensed by cGAS, a cytosolic DNA sensor, and transcribed into dsRNA by type III RNA polymerase (RNA Pol-III) to trigger the activation of the IFN …
The African swine fever virus gene MGF_360-4L inhibits ... - PubMed
2025年2月25日 · In this study, we identified a virulence gene of ASFV, MGF_360-4L, that targets and recruits the selective autophagy receptor p62 to mediate the degradation of the dsRNA …
Insights and progress on epidemic characteristics, pathogenesis, …
ASFV is the only representative of the African swine fever virus (Asfarviridae) . ASFV is classified into 25 genotypes based on sequence differences at the 3’end of the B646L gene. ... It is …
Antagonisms of ASFV towards Host Defense Mechanisms: …
2023年2月19日 · Recent studies have revealed that ASFV can employ diverse strategies to interrupt the host defense mechanisms via abundant self-encoded proteins. Thus, this review …
Modeling of the Toll-like receptor 3 and a putative Toll-like …
African swine fever virus (ASFV) is a large double-stranded DNA virus responsible for a lethal pig disease, to which no vaccine has ever been obtained. ... Viral dsRNA is recognized by the Toll …