Inhibition of ASGR1 decreases lipid levels by promoting ... - Nature
2022年8月3日 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely …
ASGR1，新一代降脂靶点前沿 - 知乎 - 知乎专栏
文章揭示了asgr1在胆固醇排泄代谢中的关键作用，通过一种涉及 lxr稳定 而无需脂质生成激活的机制促进胆固醇排泄，并通过小鼠模型的验证，证实了asgr1中和抗体和小核酸药物在临床前阶 …
代谢学人--Nature: 驱逐胆固醇，Asgr1有奇效！ - 知乎专栏
asgr1 是唾液酸糖蛋白受体的主要亚型，在肝脏中特异表达，介导血液 去唾液酸糖蛋白 的内吞并转运至溶酶体降解。在一项针对冰岛人的大规模基因研究中发现，功能缺失的asgr1变异与低胆 …
ASGR1 Gene - GeneCards | ASGR1 Protein | ASGR1 Antibody
2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B . Among its related pathways are …
Deficiency of ASGR1 promotes liver injury by increasing GP73
2024年3月8日 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male …
ASGR1: an emerging therapeutic target in hypercholesterolemia
2023年1月23日 · In a recent study, Wang et al. 1 discovered that inhibition of asialoglycoprotein receptor 1 (ASGR1) (a GWAS identified gene associated coronary artery disease) could …
Asialoglycoprotein receptor 1 - Wikipedia
The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more …
Beyond conventional treatment: ASGR1 Leading the new era of ...
2024年11月1日 · ASGR1 (asialoglycoprotein receptor 1), predominantly expressed on hepatocytes, has emerged as a key regulator of cholesterol metabolism and low-density …
一个全新靶点：会成为数亿高血脂人群的新希望吗？|巡山报告 - 知乎
ASGR1的降脂机理. 我们说回ASGR1这个靶点。ASGR1的全称是Asialoglycoprotein Receptor 1，即脱唾液酸糖蛋白受体1。顾名思义，这是细胞表面的一类受体分子，专门结合和感知一类 …
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1
2021年10月8日 · ASGR1 rescue experiments reduced INSIG1 and restored the SREBP network defect as manifested by improved apolipoprotein B secretion and reduced LDL uptake. Our …