The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Design and Methods.

2021年11月26日 · Our study revealed an interacting host receptome of SARS-CoV-2, and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,...

asgr1 是唾液酸糖蛋白受体的主要亚型，在肝脏中特异表达，介导血液 去唾液酸糖蛋白 的内吞并转运至溶酶体降解。在一项针对冰岛人的大规模基因研究中发现，功能缺失的asgr1变异与低胆固醇和cvd风险降低有关。

2023年1月23日 · In a recent study, Wang et al. 1 discovered that inhibition of asialoglycoprotein receptor 1 (ASGR1) (a GWAS identified gene associated coronary artery disease) could upregulate ABCG5, ABCG8, and...

The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Design and Methods. Using reverse transcription amplification (RT-PCR), expression of ASGR1 and ASGR2 was investigated in human peripheral blood monocytes.

2022年8月3日 · Human genetic studies have identified that the loss-of-function Asialoglycoprotein receptor 1 (ASGR1) variants associate with low cholesterol and a reduced risk of cardiovascular disease 2....

2024年2月22日 · 研究人员先在肝癌细胞系Huh-7分别敲除ACE2和ASGR1，发现只有当同时敲除ACE2和ASGR1才能够彻底阻碍新冠病毒感染肝癌细胞。...

2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.

asgr1是肝去唾液酸糖蛋白受体一个主要的亚型，具有识别和调控细胞的内吞作用以及去唾液酸糖蛋白的降解。 研究发现，del12突变会增加携带者的碱性磷酸酶和维生素B12的含量。

The asialoglycoprotein receptor contains two subunits, asialoglycoprotein receptor 1 (ASGR1) and asialoglycoprotein receptor 2 (ASGR2). These subunits may form different quaternary forms such as dimers, trimers, tetramers to allow for specific substrate binding or endocytosis.