2 天之前 · Phenobarbitone is assayed by non-aqueous titration. In this method, the drug is dissolved in the pyridine and titrated with sodium hydroxide solution using thymolphthalein as an indicator. PROCEDURE: STANDARDISATION OF SODIUM HYDROXIDE SOLUTION

ABSTRACT: The objective of the current study was to develop simple, precise and accurate stability indicating by isocratic RP-HPLC assay method and validated for determination of Phenobarbitone in solid pharmaceutical dosage forms.

Monitoring of the serum level of the drug is essential in order to achieve maximal seizure control while maintaining minimal blood levels to avoid negative side effects. Estimation of phenobarbitone levels may be useful when establishing a dosage for new patients, monitoring compliance or assessing for toxicity.

2013年5月1日 · The objective of the current study was to develop simple, precise and accurate stability indicating by isocratic RP-HPLC assay method and validated for determination of Phenobarbitone in solid pharmaceutical dosage forms.

1978年9月21日 · A rapid gas—liquid chromatographic method has been developed for the analysis of phenobarbitone, primidone and phenytoin in small (50 μl) volumes of either blood plasma or serum.

1978年1月1日 · The electrode is sensitive for the concentration range from 0.1 M to 10-5 M of phenobarbital at pH 9 . 6 , and the results obtained are in agreement with the standard USP method. The assay using the ion selective electrode can be accomplished within twenty minutes where the USP method needs four hours.

A liquid chromatographic method for the simultaneous assay of four anticonvulsant drugs, phenobarbitone, ethosuximide, phenytoin and carbamazepine on a polystyrene-divinyl benzene column is described.

Therapeutic drug monitoring of phenobarbitone or primidone. Interpretation: Phenobarbitone has a long half-life and a steady state may not be reached for several weeks. Mean half-life is 100 h (range 50-150 h). Primidone is metabolised to phenobarbitone.

1987年1月1日 · In order to develop 5-pentadeuteroethyl-5-phenyl barbituric acid as an alternative tracer in pharmacokinetic and metabolic studies of phenobarbitone, and to search for possible isotope effects associated with such labelling, we propose a gas chromatographic-mass spectrometry assay for simultaneous measurement of phenobarbitone, p ...

Assay of Phenobarbitone - Free download as PDF File (.pdf), Text File (.txt) or read online for free.