Accumulating evidence shows the complex picture of AT1 receptor-mediated signaling; AT1 receptor-mediated heterotrimeric G protein-dependent signaling, transactivation of growth factor receptors, NADPH oxidase and ROS signaling, G protein-independent signaling, including the β-arrestin signals and interaction with several AT1 receptor interactin...

AT1-AAs bind and activate g-coupled AT1 receptors to increase ANGII sensitivity and to stimulate downstream pathways to elevate circulating concentrations endothelin 1, sFlt-1, and ROS that have a pathological effect on the kidney to increase RVR, decrease RBF, and thus decrease GFR (i.e. renal function).

Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive mechanisms (ET [endothelin] and sFlt-1 [soluble fms-like tyrosine kinase-1]) …

1992年6月1日 · We have previously found a transient increase of TAT levels in congenital AT1Q deficiency patients with deep vein thrombosis after the administration of ATZ, and have demonstrated that this TAT increase in part represents the extraction of thrombin from the fibrin clots of thrombi (9).

2018年3月19日 · Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive mechanisms (ET [endothelin] and sFlt-1 [soluble fms-like tyrosine kinase-1]) in rodent models of preeclampsia.

2023年6月17日 · Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of …

2018年1月10日 · Research in recent years has discovered that agonistic autoantibody against type-1 angiotensin II receptor (AT1-AA) can exert an agonist-like effect through activation of AT1 receptors.

AT1-AA are detectable in animal models of preeclampsia and are responsible for elevation of soluble fms-related tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), oxidative stress, and endothelin-1, all of which are enhanced in preeclamptic women.

In preeclampsia, agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA) are described. They induce NADPH oxidase and the MAPK/ERK pathway leading to NF-κB and tissue factor activation.

Abstract —Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive mechanisms (ET [endothelin] and sFlt-1 [soluble fms-like tyrosine kinase-1]) in rodent models of preeclampsia.