AT1 receptor signaling pathways in the cardiovascular system
Accumulating evidence shows the complex picture of AT1 receptor-mediated signaling; AT1 receptor-mediated heterotrimeric G protein-dependent signaling, transactivation of growth …
Advances in the allostery of angiotensin II type 1 receptor
Jun 17, 2023 · Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract …
Immunohistochemical Localization of AT
Mar 19, 2013 · Ultrastructural immunogold labeling for the AT 1a receptor in glomerulosa and medullary cells localized it to plasma membrane, endocytic vesicles, multivesicular bodies, …
The role of Agonistic Autoantibodies to the Angiotensin II Type …
AT1-AAs bind and activate g-coupled AT1 receptors to increase ANGII sensitivity and to stimulate downstream pathways to elevate circulating concentrations endothelin 1, sFlt-1, and ROS that …
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody
Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive …
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) …
Mar 19, 2018 · Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, …
Angiotensin II type 1 receptor autoantibody (AT1-AA)-mediated …
AT1-AA are detectable in animal models of preeclampsia and are responsible for elevation of soluble fms-related tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), oxidative stress, and …
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