at2细胞：这些细胞立方体状，分泌肺表面活性物质，这种物质可以降低肺泡的表面张力，防止在通气过程中肺泡塌陷。值得注意的是，at2细胞还充当肺泡中的祖细胞，它们可以自我更新并在 …

2014年2月5日 · We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another …

2019年2月8日 · Alveolar type 2 progenitor cells (AT2) seem closest to clinical translation, specifying the evidence that AT2 may satisfactorily control the immune response to decrease …

这儿对 Cdc42 AT2 null小鼠的肺切片进行了针对 Tyr1068 磷酸化的EGFR （pEGFR） 的免疫染色。 pEGFR 的表达在 GFP 标记的 AT2 细胞附近的成纤维细胞中显着上调，外周多，中心少（ …

2024年9月5日 · Our findings underscore the critical role of the sustained AREG expression in AT2 cells in driving lung fibrosis. As AREG is a member of the EGF family, we sought to investigate …

2014年3月13日 · We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, …

2022年12月22日 · Here, we describe local interactions between Treg cells and an Areg-responsive population of Col14a1 + EGFR + lung mesenchymal cells that mediate type II …

2023年4月1日 · Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC …

肺泡Ⅱ-型上皮细胞(alveolar epithelial type Ⅱ cell,AT2)是构成哺乳类动物肺泡上皮的主要细胞之一,是合成和分泌肺泡表面活性物质的主要细胞。 近年来研究发现其合成和分泌功能受多种体液 …

2019年4月8日 · We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another …