Ataxin is a type of nuclear protein. The class is called ataxin because mutated forms of these proteins and their corresponding genes were found to cause progressive ataxia.. Some …

Ataxin-1 is a DNA-binding protein which in humans is encoded by the ATXN1 gene. [5] [6] Mutations in ataxin-1 cause spinocerebellar ataxia type 1, an inherited neurodegenerative …

2017年4月12日 · A decrease in ataxin-2 levels leads to a reduction in the aggregation of TDP-43, markedly increased lifespan and improved motor function in a transgenic mouse model of TDP …

2020年7月3日 · Ataxin-1[85Q] nuclear bodies are enhanced by arsenite stress. To define the suitability of the polyQ-ataxin-1 constructs GFP-ataxin-1[85Q] and MBI-ataxin-1[85Q] for …

2023年10月14日 · Targeting ataxin-2 with RfxCas13d. Because of its ability to influence TDP-43-associated toxicity 20,25,26, ataxin-2 has emerged as a potentially broadly applicable target …

Abstract Purpose of review. To provide an update on the role of Ataxin-2 gene (ATXN2) in health and neurological diseases.Recent findings. There is a growing complexity emerging on the …

2024年12月24日 · ATXN1 (Ataxin 1) is a Protein Coding gene. Diseases associated with ATXN1 include Spinocerebellar Ataxia 1 and Dentatorubral-Pallidoluysian Atrophy.Among its related …

Moreover, Ataxin-2 represses R-loop accumulation-driven genome instability in yeast and human cells. Overall, Ataxin-2 functions impact many metabolic processes and intersect with different …

RNA-binding proteins play fundamental roles in the regulation of molecular processes critical to cellular and organismal homeostasis. Recent studies have identified the RNA-binding protein …

2024年3月19日 · 此外，研究人员还考虑了ataxin-3的DUB功能的潜在神经保护效应以及ataxin-3作为DUB酶和基因转录调节因子的交叉点。 研究意义 本研究的创新点在于深入探讨了ataxin-3 …