2022年7月1日 · In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. The ATF/CREB family in mammals represents a large group of basic-region leucine zipper (bZIP) transcription factors (TFs) with many physiological functions.

In this review we focus on the transcriptional pathways that control tumor infiltrating CD8+ T cell (TIL) function. Simultaneous restraint of overlapping inhibitory pathways may confer TIL resistance to multiple mechanisms of suppression traditionally referred to as exhaustion, tolerance, or anergy.

2005年4月26日 · Here we demonstrate that systemic neutralization of TGF-β activity in mice restores expression of a distinct cytotoxic gene program in CD8+ T cells, which promotes antigen-specific tumor clearance in vivo. Current cancer therapies are designed to target the TGF-β signaling pathway primarily in the tumor.

Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN- γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells.

In this study, we demonstrate that inhibition of HO-1 activity in murine bone marrow-derived immature DCs (iDCs) resulted in DCs with raised intracellular ROS levels, a mature phenotype, impaired phagocytic and endocytic function, and increased …

该基因编码一个激活转录因子，属于 ATF 亚家族和 bZIP (碱性区亮氨酸拉链) 家族。 它通过调节与生长、存活和其他细胞活动相关的下游靶基因的表达来影响细胞生理过程。 该蛋白在其激酶诱导结构域的第 63 位丝氨酸被丝氨酸/苏氨酸激酶、cAMP 依赖性蛋白激酶 A、钙调蛋白依赖性蛋白激酶 I/II、有丝分裂原和应激激活蛋白激酶以及细胞周期蛋白依赖性激酶 3 磷酸化 ( cdk-3) .其磷酸化增强其反式激活和转录活性，并增强细胞转化。 该基因与 16 号染色体上的 FUS 或 22 号染色体上 …

2014年6月6日 · In this study, we demonstrate that inhibition of HO-1 activity in murine bone marrow-derived immature DCs (iDCs) resulted in DCs with raised intracellular ROS levels, a mature phenotype, impaired phagocytic and endocytic function, and increased capacity to stimulate antigen-specific CD8 T cells.

hyperphosphorylation of CREB/ATF1 transcription factors. Phosphorylation of CREB is known to be associated with up-regulation of CD86 and secretion of the cytokine, IL-10 cytotoxic T lymphocytes (CD8 þ T) Inhibited ATF1 inhibited the transcriptional of granzyme B and interferon g killing ability of cytotoxic T lymphocytes is reduced. Tumor cells

2017年9月11日 · CD8 + T cell contact with cognate antigen leads to intracellular T cell receptor (TCR)-mediated signaling that, along with co-stimulatory signals, orchestrates gene expression programs to control...

In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy. Keywords: Anti-tumor effect, ATF, bZIP, Cancer, Immunity, Tumorigenesis.