AuTophaGy related 1 (Atg1) is a 101.7kDa serine/threonine kinase in S.cerevisiae, encoded by the gene ATG1. [1] It is essential for the initial building of the autophagosome and Cvt …

Here, we investigated the role(s) of the Arabidopsis (Arabidopsis thaliana) ATG1 kinase during autophagy through an analysis of a quadruple mutant deficient in all four ATG1 isoforms.

2020年9月24日 · 从酵母到哺乳动物都保守的一系列自噬相关蛋白（Atg proteins）在自噬过程中发挥关键作用。其中，Atg1（哺乳动物中称为ULK1）是一个丝氨酸/苏氨酸激酶，其激酶活性对 …

Here, we describe the ATG1/13 complex in Arabidopsis thaliana and show that it is both a regulator and a target of autophagy. Plants missing ATG13 are hypersensitive to nutrient …

2021年11月18日 · Combining in vitro reconstitution and cell-based approaches, we demonstrate that Atg1 is activated by lipidated Atg8 (Atg8-PE), stimulating substrate phosphorylation along …

Here, we show that Atg11 is phosphorylated by Atg1. Rapamycin treatment or starvation conditions induced slower electrophoretic mobility of Atg11 in an Atg1 kinase activity …

2008年4月25日 · ATG1 is located on the left arm of chromosome VII between GTS1 and replication origin ARS707; coding sequence is 2694 nucleotides long with 3 SNPs, 1 of which …

2022年4月1日 · In this review, we summarize the current knowledge of the structure and basic/essential molecular functions of the ATG1/ATG13 complex in plants, especially ATG1 …

ATG1 encodes a protein kinase, and the catalytic activity of Atg1 is essential for autophagy (19, 28). Atg1 forms a complex with several proteins, including Atg11, Atg13, Atg17, Atg29, and …

In this study, we examined the role of proteins that comprise the Atg1 kinase complex in PAS assembly. Our results suggest that Atg1, Atg13, and Atg17 have a critical role in PAS …