2024年12月24日 · ATG10 (Autophagy Related 10) is a Protein Coding gene. Diseases associated with ATG10 include Neurodegeneration With Brain Iron Accumulation and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways are Autophagy and Selective autophagy.

Autophagy-related protein 10 is a protein that in humans is encoded by the ATG10 gene. [5]

2023年11月30日 · atg10是一种e2样酶，结构上具有用于催化蛋白质脂质化的活性位点。 它通过与ATG7（E1样酶）和ATG8家族蛋白相互作用，促进ATG8蛋白的磷脂酰乙醇胺（PE）结合，从而有助于自噬囊泡的形成和扩展。

2017年9月12日 · We report distinct effects of two autophagy-related protein ATG10s on HCV-subgenomic replication. ATG10, a canonical long isoform in autophagy process, can facilitate HCV-subgenomic replicon...

2019年8月1日 · CgATG10 might be involved in oyster innate immune response by regulating the autophagosome formation of autophagy, which could inhibit the expression of CgIRF-1 and negatively regulate the interferon system during anti-virus immune response. These results would provide referential information about the autophagy process in bivalves, and also be ...

ATG10 is an E2-like Enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by …

2019年8月1日 · ATG10 is an important adaptor to recruit other molecules for complex conjugation and plays the key roles in the second step of autophagosome formation. Previous study has revealed that ATG10 is a new type of protein-conjugating enzyme to form the ATG12-ATG10 thioester intermediate, which then conjugates ATG5 to form the ATG12-ATG5 conjugation ...

2023年11月22日 · ATG10（Autophagy-related 10）重组蛋白是自噬过程中关键的调控分子，参与了细胞内垃圾清理和细胞自我调节的重要步骤。 本文将深入探讨ATG10重组蛋白的结构特征、功能目录号（PA1000-262)以及其在自噬过程和相关疾病中的作用。

In the present study, an autophagy-related protein ATG10 (designated as CgATG10) was identified from Pacific oyster Crassostrea gigas. The open reading frame of CgATG10 cDNA was of 621 bp, encoding a polypeptide of 206 amino acid residues with an Autophagy_act_C domain (from 96 to 123 amino acid), which shared high homology with that from C ...

ATG10 Protein, Human (GST)是一种在 E. coli 中表达的，末端有 GST 标签的重组人 Autophagy Related 10 Homolog (ATG10)。ATG10 是一种 E2 泛素结合酶，参与自噬体形成所必需的 2 种泛素样修饰。

2024年12月3日 · ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by …

2024年6月17日 · ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by …

Autophagy-related 10 (ATG10), also known as APG10 and APG10L, is an E2-like enzyme involved in ubiquitin-like modifications necessary for autophagosome formation. Accumulating evidence has substantiated that ATG10 plays an important role in the carcinogenesis of lung, colorectal, and gastric cancers [9 - 14].

2025年2月8日 · ATG10, a canonical long isoform in autophagy process, can facilitate hepatitis C virus-subgenomic replicon amplification by promoting autophagosome formation and by combining with and detaining autophagosomes in cellular …

ATG10S is a newly discovered subtype of the autophagy protein ATG10. It promotes complete macroautophagy/autophagy, degrades multiple viral proteins, and increases the expression of type III interferons. Here, we aimed to investigate the mechanism of ATG10S cooperation with IFNL1 to degrade viral pr …

2018年9月24日 · Autophagy-related 10 (ATG10) is essential for autophagy since it promotes ATG5-ATG12 complex formation. Our previous study found that there are two isoforms of the ATG10 protein, ATG10 (a longer one) and ATG10S, which have identical sequences except an absence of a 36-amino acid fragment (peptide B) …

摘要: 为了研究自噬相关基因ATG10(Autophagy related gene 10)在鱼类免疫应答中的功能, 研究克隆了大黄鱼(Larimichthys crocea)ATG10基因(LcATG10)的cDNA序列, 其开放阅读框全长747个核苷酸, 编码248个氨基酸的蛋白, 包含1个Autophagy_act_C结构域。系统进化分析显示, LcATG10和其 …

2012年7月3日 · Here, we report the solution and crystal structures of Atg10 and Atg5 homologs from Kluyveromyces marxianus (Km), a thermotolerant yeast. KmAtg10 comprises an E2-core fold with characteristic accessories, including two β strands, whereas KmAtg5 has two ubiquitin-like domains and a helical domain.

2024年8月7日 · Accordingly, DDX10 deficiency may aggravate autophagy mediated by ATG10 to impede cell proliferation, stemness and facilitate cell apoptosis, hence blocking the progression of CRC. Keywords: ATG; Autophagy; Colorectal cancer; DDX10; Stemness.

2012年7月3日 · Here, we determined the solution structure of Atg10 using a thermotolerant yeast homolog, KmAtg10, and showed that Atg10 has an E2-core fold with noncanonical, characteristic accessories. NMR and biochemical analyses demonstrated that Atg10 directly interacts with Atg5 using β5 and β6, the characteristic accessories, and revealed the critical ...