ATG14 promotes membrane tethering and fusion of …
2015年4月23日 · Here we report that ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the …
Nat Commun丨揭示ATG14做为自噬受体介导脂滴自噬机制和功能
ATG14 是自噬起始复合物 PI3KC3-C1 的重要成员，与VPS34、 Beclin1 和 p150 形成PI3KC3-C1复合物，介导磷脂酰肌醇3-磷酸（PI3P）的产生，以此来启动自噬前体的形成。 在最终自 …
Beclin 1–ATG14L Protein–Protein Interaction Inhibitor Selectively ...
2020年4月22日 · This molecule is a promising new tool that is critical for understanding how modulation of the Beclin 1–ATG14L interaction affects autophagy. More broadly, its discovery …
Plant Cell | 刘芬博士等揭示自噬蛋白ATG14介导PI3K复合体调控植 …
该研究首次鉴定了两个拟南芥 ATG14 同源基因，分别命名为 ATG14a 和 ATG14b，并证明了ATG14和PI3K复合体成员ATG6存在互作关系。 为了研究ATG14的功能，作者通过 …
ATG14 targets lipid droplets and acts as an autophagic ... - Nature
2024年1月20日 · In this study, we showed that ATG14 targets LDs, interacts with ATG8s via LC3 interaction region (LIR), and acts as an autophagic receptor to regulate LD turnover via …
Two Beclin 1-binding proteins, Atg14L and Rubicon ... - Nature
2009年3月8日 · Here, we have identified two Beclin 1 associated proteins, Atg14L and Rubicon. Atg14L and UVRAG bind to Beclin 1 in a mutually exclusive manner, whereas Rubicon binds …
ATG14 promotes membrane tethering and fusion of …
2015年2月9日 · Here we report that ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the class III …
Molecular characterization and expression of the autophagy
Atg14 (autophagy-related gene 14), also known as Atg14L or Barkor (Beclin-1 associated autophagy-related key regulator), plays an important role in a variety of biological processes …
Autophagy requires endoplasmic reticulum targeting of the …
2010年8月23日 · Recently, an autophagy-specific phosphatidylinositol 3-kinase (PI3-kinase) complex, consisting of hVps34, hVps15, Beclin-1, and Atg14L, has been identified in …
自噬相关 14（ATG14）基因 | MCE - MCE-生物活性分子大师
Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of …