2024年12月24日 · ATG2A (Autophagy Related 2A) is a Protein Coding gene. Diseases associated with ATG2A include Neurodegeneration With Brain Iron Accumulation and Neurodegeneration With Brain Iron Accumulation 5. Among its related pathways are Alzheimer's disease and miRNA effects and Autophagy. An important paralog of this gene is ATG2B.

2024年8月2日 · Here we report the cryo-electron microscopy structures of human ATG2A in complex with WD-repeat protein interacting with phosphoinositides 4 (WIPI4) at 3.2 Å and the ATG2A–WIPI4–ATG9A complex...

2019年6月3日 · Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the ER-autophagosome interface. ATG2A can bind tens of glycerophospholipids at once and transfers lipids robustly in vitro.

2024年4月16日 · In summary, we propose that ATG2A transfers lipids including PI3P from endosomes to phagophores, with ANKFY1 bridging its interaction with endosomes. To dissect how ATG2A transfers lipids for...

2022年11月17日 · ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes. Although both have been functionally linked during the formation of autophagosomes, the molecular details and consequences of their interaction remain unclear.

2019年7月4日 · Autophagy-related 2 (ATG2), the rod-shaped protein that tethers phosphatidylinositol 3-phosphate (PI3P)-enriched phagophores to the endoplasmic reticulum (ER), is suggested to be essential for phagophore expansion, but the underlying mechanism remains unclear. Here, we demonstrate that human ATG2A is a lipid transfer protein.

预计可启用磷脂酰肌醇 3 磷酸结合活性。 参与自噬体组装。 预测位于内质网膜；脂滴;和吞噬泡组装位点膜。 预计在吞噬细胞组装位点活跃。 预测为膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane.

Here, we report the identification and characterization of mammalian Atg2 homologues Atg2A and Atg2B. Simultaneous silencing of Atg2A and Atg2B causes a block in autophagic flux and accumulation of unclosed autophagic structures containing most Atg proteins. Atg2A localizes on the autophagic membrane, as well as on the surface of lipid droplets.

2023年8月14日 · We mutated key amino acids within the bridge to form a transport-dead ATG2 mutant (TD-ATG2A) which we show specifically blocks bridge-like, but not shuttle-like, lipid transport in vitro. TD-ATG2A still localizes to LDs, but is unable to rescue LD accumulation in ATG2 knockout cells.

2021年8月1日 · Recent structural and biochemical analyses have revealed that two mysterious autophagy-related (Atg) proteins, Atg2 and Atg9, are novel types of intermembrane and interleaflet lipid transporters, respectively.