Each milliliter of ATGAM contains 50 mg of horse gamma globulin stabilized in 0.3 molar glycine to a pH of approximately 6.8. ATGAM sterile solution is a lymphocyte-selective immunosuppressant as is demonstrated by its ability to reduce the number of circulating, thymus-dependent lymphocytes that form rosettes with sheep erythrocytes.

Each 5 mL ampoules contains 50 mg lyophilized ATG (Equine) per mL. Concentrate for solution for infusion. Pharmacodynamic properties). ATGAM is indicated for the treatment of moderate to severe aplastic anemia in patients unsuitable for bone marrow transplantation (see section 5.2 Pharmacodynamic properties).

ATGAM® (lymphocyte immune globulin, anti-thymocyte globulin [equine] sterile solution) This product information is intended only for residents of the United States. for Consumers: ATGAM - U.S. Medical Information Page - patient information, ways to contact Pfizer Medical & other resources; for Healthcare professionals:

2023年12月12日 · Atgam has induced instances of partial or complete haematologic recovery and improved survival in patients with aplastic anaemia of known or suspected immunologic aetiology in patients who are unsuitable for bone marrow transplant.

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2024年6月18日 · ATGAM Sterile Solution contains lymphocyte immune globulin, anti-thymocyte globulin [equine]. It is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymus lymphocytes. ATGAM is a transparent to slightly opalescent aqueous protein solution.

ATGAM is indicated for the treatment of moderate to severe aplastic anaemia in patients who are unsuitable for bone marrow transplantation. commencing treatment. A conservative, conventional approach would first employ epicutaneous (prick) testing. with undiluted ATGAM.

Atgam（Antithymocyte Globulin Equine）是一种免疫抑制剂的无菌溶液，用于 治疗肾移植排斥反应和再生障碍性贫血 。 作用机制 Atgam是由结合淋巴细胞表面多种蛋白质的抗体组成的。此外，Atgam与粒细胞、血小板和骨髓细胞结合。Atgam诱导免疫抑制的机制尚未确定。

ATGAM Sterile Solution contains lymphocyte immune globulin, anti-thymocyte globulin [equine]. It is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymus lymphocytes.

近日，美国食品和药物管理局（FDA）已批准Atgam (lymphocyte immune globulin,anti-thymocyte globulin [equine])上市， 用于肾移植排斥反应。 不适合骨髓移植的再生障碍性贫血（中度至重度）。 Atgam是一种多克隆抗体或免疫球蛋白，以静脉（IV，静脉）输注的形式给予。 对抗一种名为T淋巴细胞（也称为胸腺细胞或T细胞）的白细胞。 T淋巴细胞是免疫系统的一部分。 在血液疾病（再生障碍性贫血、骨髓增生异常综合征）中，T淋巴细胞可能会错误地攻击骨髓。 使骨髓很 …