ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. [5] [6] In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B.

2024年12月24日 · ATOX1 (Antioxidant 1 Copper Chaperone) is a Protein Coding gene. Diseases associated with ATOX1 include Menkes Disease and Wilson Disease. Among its related pathways are Cellular responses to stimuli and Innate Immune System. Gene Ontology (GO) annotations related to this gene include copper ion binding and copper-dependent protein binding.

2022年12月19日 · 伴侣抗氧化剂1 (atox1)负责将铜转移到高尔基体反面网络 (tgn) 中的atp7a和atp7b，并促进赖氨酰氧化酶、酪氨酸酶和血浆铜蓝蛋白等铜酶的合成（图 1）。 伴侣蛋白CCS将Cu递送至超氧化物歧化酶1 (SOD1)，以解毒ROS并维持Cu稳态（图 1）。

2024年3月30日 · 铜离子可以通过抗氧化剂1铜伴侣（atox1）携带到反式高尔基网络。atox1与细胞质中的cu（i）结合，并将其递送至高尔基体网络中的铜转运atp酶，如atp7a和atp7b（图1）。ccs和atox1也可以将铜转运到细胞核，在那里这种金属参与各种转录因子的激活（图1）。 铜螯合

Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway. This process is required for activation of ...

2024年3月14日 · Copper is also transported to the trans-Golgi by antioxidant 1 copper chaperone (ATOX1). Copper can be delivered by CCS to the nucleus, where it activates transcription factors such as hypoxia ...

2023年9月13日 · The ATOX1 (Antioxidant Protein 1) is a human copper metal chaperone that plays an important role in cellular copper homeostasis. The protein is responsible for cytosolic copper absorption from CTR1 (copper transporter 1) and transport to the copper pumps in the Trans Golgi network to the ATP7A and ATP7B proteins.

The present study with re-expression of nuclear-targeted Atox1 in Atox1-/-cells strongly suggests that it is nuclear Atox1 that plays an essential role in copper-stimulated increases in cyclin D1 expression and cell proliferation.

抗氧化因子 1 铜伴侣： 该基因编码一个铜伴侣蛋白，它通过将胞质铜结合并转运到反式高尔基体网络中的 ATP 酶蛋白，以便随后掺入血浆铜蓝蛋白，从而在铜稳态中发挥作用。这种蛋白质还可以作为抗超氧化物和过氧化氢的抗氧化剂，因此可能在癌症发生中发挥重要作用。由于其细胞遗传学 …

铜伴侣蛋白 Atox1，能够将细胞质中的Cu（I）从铜输入器Ctr1移动到高尔基网络中的 ATP 酶 ATP7A 和 ATP7B，以负载分泌通路中的Cu依赖酶，促进癌细胞的迁移。