Atrial natriuretic peptide (ANP) was discovered by de Bold et al. [25,26] as an endogenous diuretic peptide stored in atrial granules. Other natriuretic peptides such as brain natriuretic peptide (BNP), C- type natriuretic peptide (CNP), and urodilatin (ANP 95–126) have been also discovered [129,130] .

Natriuretic peptides are peptide proteins secreted from cardiomyocytes in the atria (atrial natriuretic peptide and mid-regional proatrial natriuretic peptide) and the ventricles (brain natriuretic peptide, BNP) in response to myocyte stretch from volume or pressure overload [40]. Upon stimulation, proBNP is synthetized de novo, mostly from ...

2010年11月1日 · The peptide was designated as ANP, and exhibits diuretic, natriuretic, and vasodilating activities. Following the discovery of ANP, Matsuo and Kangawa also isolated brain natriuretic peptide, or B-type natriuretic peptide (BNP) from the porcine brain in 1988 [10], and C-type natriuretic peptide (CNP) from the porcine brain in 1990 [11].

Atrial natriuretic peptide (ANP), a 28-amino acid peptide first isolated from rat atrial cardiocytes (1), has potent natriuretic, diuretic, and vasorelaxant properties (2–4). Additionally, it inhibits the secretion of renin, aldosterone, and vasopressin, all of which are involved in body fluid homeostasis ( 5 ).

Atrial natriuretic peptide (ANP), a 28-amino acid peptide first isolated from rat atrial cardiocytes (1), has potent natriuretic, diuretic, and vasorelaxant properties (2–4). Additionally, it inhibits the secretion of renin, aldosterone, and vasopressin, all of which are involved in body fluid homeostasis ( 5 ).

2015年9月10日 · Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation. ANP also has an anti-hypertrophic function in the heart, which is independent of its systemic blood pressure-lowering effect.

1997年1月1日 · Atrial natriuretic peptide (ANP) was first sequenced in 1984 [ 1] and has subsequently been the subject of exten- sive investigation. This peptide is secreted from the cardiac atria and has pro- found natriuretic and diuretic properties, as …

2019年2月1日 · In the present work we sought to establish whether atrial natriuretic peptide (ANP) alleviated ER stress in rats with cerulein-induced pancreatitis. The major components of the unfolded protein response (UPR) and their downstream effectors were assessed by immunoblotting or fluorimetry and the ultrastructure of ER evaluated by electron ...

2019年1月1日 · The natriuretic peptide family consists of three biologically active peptides: atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Among these, ANP and BNP are secreted …

2020年8月25日 · Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo . Here, we show that acute cold exposure induces cardiac ANP secretion in …