This review article concentrates on the Atrophin family proteins, including vertebrate Atrophin-1 (ATN1), vertebrate arginine-glutamic acid dipeptide repeats protein (RERE), and Drosophila Atrophin (Atro), which we recently identified as nuclear receptor corepressors.

Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. [5] The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. [6] The function of Atrophin-1 has not yet been determined. [7]

2024年12月24日 · ATN1 (Atrophin 1) is a Protein Coding gene. Diseases associated with ATN1 include Dentatorubral-Pallidoluysian Atrophy and Congenital Hypotonia, Epilepsy, Developmental Delay, And Digital Anomalies. Among its related pathways are PIP3 activates AKT signaling and Signal Transduction.

阿托品 （英語： atropine）或譯 阿托平，又稱 颠茄碱[1]，是一種属于 抗膽鹼劑 中的 抗毒蕈碱药，用來治療 神經毒氣 或 殺蟲劑中毒 （英语：Pesticide poisoning），也用在某些 心跳過緩，與手術時減少唾液分泌 [2]，一般會以 靜脈注射 或肌肉注射給藥 [2]，眼藥水劑型用於治療 葡萄膜炎 與早期 弱視，以及控制 近视 [3]。 靜脈注射劑型的藥物，在一分鐘內就會生效，並持續半小時到一小時左右 [4]。 若是治療中毒，可能需要較高劑量的阿托品 [2]。 阿托品是一種 蕈毒鹼受器阻斷 …

Atrophin proteins are conserved transcriptional corepressors that, as we recently demonstrated, are involved in nuclear receptor signaling.This review article provides an overview of our current understanding of this new class of nuclear receptor corepressors, which includes vertebrate Atrophin-1 (ATN1), vertebrate arginine glutamic acid repeats...

2023年10月4日 · Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p.

2023年2月21日 · Dentatorubral–pallidoluysian atrophy (DRPLA) is a rare, incurable genetic disease that belongs to the group of polyglutamine (polyQ) diseases. DRPLA is the most common in the Japanese population; however, its global prevalence is also increasing due to …

2017年3月22日 · Atrophins are a group of co-repressors found in many animals including humans and fruit flies. Atrophins suppress the activity of certain genes, reducing the effects that they have in the cell. Losing Atrophin from cells can lead to severe diseases, but how Atrophin causes these effects is currently not well understood.

2007年2月16日 · Vertebrate genomes harbor two Atrophin genes, Atrophin-1 (Atn1) and Atrophin-2 (Atn2). The Atn1 locus produces a single polypeptide, whereas two different protein products are expressed from the Atn2 (also known as Rere) locus. A long, or full-length, form contains an amino-terminal MTA-2-homologous domain followed by an Atrophin-1-related domain.

2019年7月3日 · The ATN1 gene encodes atrophin-1, a member of a class of evolutionarily conserved transcriptional corepressors involved in nuclear signaling. ATN1 is believed to play a role as a nuclear transcriptional regulator important for brain and other organ system development (summary by Palmer et al., 2019 ).