2024年12月24日 · ATRX (ATRX Chromatin Remodeler) is a Protein Coding gene. Diseases associated with ATRX include Alpha-Thalassemia Myelodysplasia Syndrome and Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1. Among its related pathways are Alternative Lengthening of Telomeres (ALT) and Chromosome Maintenance.

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene. [5][6][7]

转录调控因子ATRX 又称作 ATP依赖的解旋酶ATRX、X连锁的解旋酶II，或 X连锁的核蛋白（XNP），在人类这是一种由ATRX基因编码的蛋白。 一个 胶质瘤 标本分子检测后，发现有ATRX 突变，这是好事，说明这个瘤子还很善良。 实际上ATRX 突变总是和 IDH 突变相伴随。 我们也知道，和IDH1/2野生型胶质瘤相比，IDH1/2突变型胶质瘤患者通常生存期较长。 所以实际上，完全可以只检测IDH1/2有无突变来代替ATRX有无突变的检测。 这里要明白，检测实施时，科学家 …

2024年1月25日 · In this investigation, we leverage multiple glioma models to demonstrate that ATRX deficiency leads to increased innate immune signaling and cytokine secretion in response to dsRNA-based innate...

2023年6月1日 · ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state, gene expression, and DNA damage repair, placing ATRX as a central player in the...

2023年3月7日 · ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state, gene expression, and DNA damage repair, placing ATRX as a central player in the...

ATRX基因是α地中海贫血伴智力低下综合征的致病基因，其突变在十多种癌症中都有被发现，其中包括胶质瘤、骨肉瘤和胰腺神经内分泌肿瘤等。

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state, gene expression, and DNA damage …

2021年6月23日 · ATRX is a chromatin remodeling protein of the SWI/SNF family, mutations in which cause alpha thalassemia X-linked (ATRX) intellectual disability syndrome and are highly associated with a number...

4 天之前 · ATRX is a member of the SWI/SNF family of ATP-dependent chromatin remodellers. In humans, loss of ATRX function leads to ATRX syndrome, a neurodevelopmental disorder. ATRX mutation in human cell lines is associated with multiple phenotypes including activation of the alternative lengthening of telomere (ALT) pathway, upregulation of retrotransposons and increased sensitivity to replication ...