Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene. [5][6][7] DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity.

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Using auxilin KO mice, Vidyadhara et al. show that synaptic vesicle sorting deficits, cytoplasmic dopamine accumulation, dopamine transporter mistrafficking, and synaptic autophagic overload may lead to pathogenesis of Parkinson’s disease in patients.

auxilin An adaptin associated with the coated vesicles in brain cell proteins which acts as co-chaperone to support the Hsc70-dependent clathrin uncoating of clathrin-coated vesicles, which also plays a role in recycling synaptic vesicles.

2021年2月15日 · Auxilin is a J-domain-containing defense-related protein involved in clathrin-mediated endocytosis (CME) and acts on many organisms including yeast, Caenorhabditis elegans, Drosophila, Arabidopsis thaliana and rice. Auxilin regulates biological

2018年3月6日 · We found that overexpression of AUXILIN-LIKE1 and AUXILIN-LIKE2 caused an arrest of growth and development and inhibition of endocytosis, likely by preventing clathrin recruitment to endocytic pits initiated by the adaptor proteins.

Auxilin, the putative tyrosine-protein phosphatase encoded by DNAJC6, was remarkably higher expressed in the fetal compared to the adult heart both before and during the risk period for CHB (>10 fold, p< 0.001).

Auxilin is a specialized member of the DnaJ protein family and functions as an essential cofactor to HsclO in the uncoating of clathrin coated vesicles. Auxilin associates preferentially with polymeric clathrin and captures with its carboxyl-terminal J domain the uncoating protein HsclO.

1990年7月1日 · We propose for the new protein the name auxilin (Latin auxilium, meaning support). Auxilin migrates as a 110-kD polypeptide in standard type SDS-PAGE, but in the presence of 6 M urea shifts to a position corresponding to 126 kD.

This study implicates the Drosophila GAK homolog, auxilin (aux), in a broad spectrum of parkinsonian-like symptoms. Downregulating aux expression leads to progressive loss of climbing ability, decreased lifespan, and age-dependent DA neuron death similar to …