2007年8月16日 · Axin(轴蛋白)是一个体轴发育抑制因子，作为构架蛋白在Wnt信号转导途径中起着关键的作用。Axin通过不同的机制调节β连环蛋白的磷酸化和稳定性。

2019年9月18日 · The paralogous scaffold proteins axin and conductin/axin2 are key factors in the negative regulation of the Wnt pathway transcription factor β-catenin, thereby representing interesting targets ...

Axin is a negative regulator of Wnt/beta-catenin signaling via regulating the level of beta-catenin, which is a key effector molecule. Therefore, controlling the level of Axin is a critical step for the regulation of Wnt/beta-catenin signaling.

Wnt信号转导途径是调控细胞形状、运动、黏附、增殖、分化、癌变及机体发育等过程的主要途径之一.Axin...

Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a normal cellular state. Mutations inactivating the APC gene are found in approximately 80% of all human colorectal cancer (CRC).

2023年4月12日 · Here, we show that endogenous cell competition occurs and intrinsically correlates with the Axin2 expression level during normal brain development. Induction of genetic mosaicism predisposes Axin2-deficient NPCs to behave as “losers” in mice and undergo apoptotic elimination, but homogeneous ablation of Axin2 does not promote cell death.

2009年4月24日 · Axin is known to have an important role in the degradation of β‐catenin in the Wnt pathway. Here, we reveal a new function of Axin at the centrosome. Axin was localized to the centrosome in various cell lines and formed a complex with γ‐tubulin.

Axin is known to have an important role in the degradation of b-catenin in the Wnt pathway. Here, we reveal a new function of Axin at the centrosome. Axin was localized to the centrosome in various cell lines and formed a complex with c-tubulin. Knockdown of Axin reduced the localization of c-tubulin and

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 …

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