2019年11月4日 · Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling pathway is associated with tumour cell growth, metastasis, invasion, epithelial-mesenchymal …

2019年6月6日 · Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies.

2019年11月4日 · Different therapeutic agents targeting AXL have been developed, including 1) small molecule inhibitors that block AXL auto-phosphorylation and kinase activities; 2) anti-AXL monoclonal antibodies (mAbs); 3) nucleotide aptamers; 4) soluble receptors; and 5) several natural compounds

2019年5月14日 · The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a …

2019年5月26日 · Bemcentinib (BGB324) is a first-in-class, oral, highly selective and potent AXL inhibitor which has been demonstrated to enhance anti-PD1 therapy in the pre-clinical setting.

A.X.L. is a 2018 American science fiction adventure film written and directed by Oliver Daly and starring Alex Neustaedter, Becky G, Alex MacNicoll, Dominic Rains, and Thomas Jane. It tells the story of a teenage boy who encounters a robotic dog …

癌症免疫治疗学会2019年大会报道，AXL抑制剂 Bemcentinib 联合K药二线治疗晚期肺腺癌， AXL阳性 患者的 客观缓解率达33%，疾病控制率73%，中位无进展生存期达8.4个月。

酪氨酸蛋白激酶受体（Axl）是一种跨膜蛋白，具有促进细胞的生长、迁移、聚集、转移和黏附等生物学功能，在癌症与2019新型冠状病毒（2019-nCoV）等的研究中具有重要作用。

AXL 作为一种调控多个下游信号通路的 受体酪氨酸激酶，在肿瘤的形成、增长及扩散中起到重要作用。这些过程包括了癌细胞的增殖、入侵、迁移, 上皮间质细胞转化 (EMT), 维持干细胞特性, 肿瘤血管生成, 以及 肿瘤微环境 中的免疫调节等。

AXL stock yearly return 2019, table and charts, presented by AverageAnnualReturn.com