2016年12月7日 · AXL expression stabilizes MDMX and MDM2 and suppresses p53 transcriptional activity. AXL was identified by a mammalian two-hybrid screening assay performed to search for oncogenic pathways that could affect p53 activity through regulating the MDMX–MDM2 complex (data not shown).

2020年9月25日 · In the current report, we investigated AXL regulation of TP53 transcription, expression, and biological function in mesothelioma. AXL expression was stronger in mesothelioma than most of the other tumor types from the TCGA gene expression profile dataset.

2 天之前 · AXL, a receptor tyrosine kinase, has recently emerged as a potential therapeutic target against various types of cancer. ... the cell cycle, the mTOR pathway, the AMPK pathway, the p53 pathway ...

2022年9月28日 · High levels of AXL and positive p53 expression were detected in 26.1% and 53.3% of the pretreatment EGFR-mutated NSCLC tumors, respectively. The high levels of AXL expression were associated with significantly shorter PFS with osimertinib than low levels of AXL expression, irrespective of EGFR activating mutation status.

2020年9月25日 · In the studies reported herein we demonstrate that AXL activation causes p53 functional inactivation in mesothelioma. Specifically, we show that AXL suppresses p53 expression by binding to DNA sequences upstream from the p53 gene, thereby blocking transcription of p53 DNA into RNA.

High levels of AXL and positive-p53 expression were detected in 26.1% and 53.3% of the pretreatment EGFR-mutated NSCLC tumors, respectively. High AXL expression levels were significantly associated with a shorter progression-free survival compared with low AXL expression levels, irrespective of the EGFR activating mutation status (p = 0.026).

2017年4月1日 · In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX-MDM2 heterocomplex and the activity of p53 in melanoma cells. Our data demonstrated that AXL overexpression or activation through growth arrest-specific 6 (Gas6) ligand stimulation increases MDMX and MDM2 protein levels and decreases p53 ...

2020年9月25日 · 在本文报道的研究中，我们证明 axl 激活导致间皮瘤中 p53 功能失活。具体而言，我们表明 axl 通过与 p53 基因上游的 dna 序列结合来抑制 p53 表达，从而阻止 p53 dna 转录为 rna。我们还表明选择性药物对 axl 的抑制会抑制间皮瘤细胞的活力、迁移和侵袭。

To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between AXL and TP53.

2016年12月7日 · Our findings offer an insight into a novel signalling axis linking AXL to p53 and provide a potentially druggable pathway to restore p53 function in melanoma. One of the hallmarks of malignant tumour development is loss of p53, either via mutation or …