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2022年2月21日 · Azide-modified nucleosides are important building blocks for RNA and DNA functionalization by click chemistry based on azide-alkyne cycloaddition. This has put demand on synthetic chemistry to develop approaches for the preparation of …

Our recent work on azido-DNA-model systems showed that radiation-produced electrons can be converted to highly damaging aminyl radicals (RNH•) which do have the potential to cause strand breaks. 50 Experimental studies in our labs (both in vitro and in vivo) have shown that 2-deoxy-D-glucose (2-DG), a glucose mimic and glycolytic inhibitor ...

2021年11月11日 · We have synthesized various 2′- and 3′-azido modified nucleosides and immobilized them on controlled pore glass (CPG) to be used as starting material for the synthesis of oligonucleotides (ONs) with 3′-terminal azide (attached to C2′ or C3′).

an azido sugar were used successfully in the copper(I)-catalyzed cycloaddition producing diversely 1,4-substituted [1,2,3]-triazoles in peptide backbones or side chains. The reaction conditions were fully compatible with solid-phase peptide synthesis on polar supports. The copper(I) catalysis is

We suggest that 2-DG will be a potential adjuvant to enhance the efficacy of LDRT in the treatment of COVID-19 pneumonia. Withal, azido analog of 2-DG, 2-azido-2-DG can produce rapid catastrophic oxidative stress and quell the cytokine storm in critically ill COVID-19 patients.",

3′-Azido-ddGTP 100mM Sodium Solution 94059-38-8 (free acid)；ddNTP006-0.1；ddNTP006-1；ddNTP006-10；ddNTP006-100

2025年2月1日 · A new acid-degradable linker, termed ‘azido-acetal’, rapidly hydrolyzes in endosomes but is also stable at pH 7.4. The azido-acetal has a pH 6.0 hydrolysis half-life (t ½) of 14.8 min and a hydrolysis t ½ of 21 days at pH 7.4. The azido-acetal was used to synthesize three new acid-degradable lipids and lipid nanoparticles, which were ...

Azido-PEG2-C2-amine 是一种点击化学试剂。 它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。 它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

For in vitro enzymatic incorporation of azido-sugars into specific, targeted glycans. Detect the presence or absence of GalNAc modifications. Monitoring O-glycans. Key Features and Benefits. Can be introduced to proteins and lipids via various GalNAc transferases. Can be conjugated to desired reporter molecules via click chemistry.