FAF is extremely useful in defining the areas of retinal involvement and monitor for signs of progression. FAF documents the presence and distribution of lipofuscin in the RPE cells; a decrease in autofluorescence indicates loss or damage to the RPE cells with hyperautofluorescence indicating increased metabolic activity.

To determine if ultra-wide-field fundus autofluorescence (UWFFAF) findings in acute zonal occult outer retinopathy (AZOOR) correlated well with perimetry, optical coherence tomography (OCT), and electroretinography (ERG) findings.

急 性 区 域 性 隐 匿 性 外 层 视 网 膜 病 变 (acute zonal occult outer retinopathy, AZOOR)是一种外层视网膜急性区域性损伤的特发性临床疾病，其最初表现为眼底镜下无异常。 AZOOR由Gass于1993年首次描述 (Gass1993)，其特征为急性发病的暗点，通常伴有单眼或双眼闪光、极轻微的眼底改变 (图 6.1)，以及通过视网膜电流图 (ERG)和谱域光学相干断层扫描 (SD-OCT)检测到的外层视网膜的功能和形态损害 (Gass 等 2002; Saito 等 2015)。 受AZOOR影响的视网膜部位经常 …

Numerous imaging modalities have been used to characterize and monitor patients with AZOOR. The most common are fundus photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA).

2019年8月11日 · 急性区域性隐匿性外层视网膜病变（AZOOR）是一种少见的视网膜功能障碍性疾病，多表现为急性起病，早期眼底未见特异性改变。 虽然称之为“急性区域性隐匿性外层视网膜病变”，但AZOOR的病理变化远不止这么简单，临床表现的隐匿性和复杂性使其诊断和治疗尤为艰难。 北京协和医院陈有信教授就AZOOR的诊疗进展展开讲解，辅以精彩的病例分析和珍贵影像学资料，揭开了这一“隐匿性”眼病的神秘面纱。 一个高度近视的患者，矫正视力1.0，除了高度近 …

2018年8月29日 · FAF in both eyes revealed a trizonal pattern and a demarcating hyper-FAF line between the involved and uninvolved retina (Fig. 7); these findings were suggestive of AZOOR . After 2 months, a progression of the zonal lesions was found in both eyes; in the RE, the progression occurred around the disc and towards the fovea and development of a ...

The most rewarding imaging modalities for AZOOR were without doubt SD-OCT showing photoreceptor outer segment damage and, even more so, blue light FAF delineating the extension of lesions [22,23,24]. As AZOOR is a rare disease, no therapeutic trials have been conducted and treatment is empirical.

Purpose: To evaluate the fundus autofluorescence (FAF) findings in eyes with acute zonal occult outer retinopathy (AZOOR) and the relationships between the FAF, spectral-domain optical coherence tomography (SD-OCT), and Humphrey visual field (HVF) findings.

2024年1月1日 · The acute zonal occult outer retinopathy (AZOOR) is a rare and autoimmune disease that causes photoreceptor dysfunction and visual field defects. It was described first by J.D. Gass [1] in 1993. The diagnosis of AZOOR can be difficult because there is no particular diagnostic test available.

The trizonal pattern of FAF imaging is a defining feature of AZOOR, particularly the hyperautofluorescent line demarcating the normal retina from the AZOOR lesion. With ICG angiography, a trizonal pattern is observed as well.