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Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent nucleos (t)ide analogues (NUCs) recommended as first-line monotherapies for chronic hepatitis B. In Phase III trials, ETV and TDF demonstrated superior efficacy, and comparable safety ...

2014年5月23日 · 参照我国及亚太CHB指南，ETV用于CHB患者抗病毒治疗的一般适应证为：a=HBeAg阳性患者 HBV DNA 载量≥ 5 log10拷贝/ml，HBeAg阴性患者HBV DNA载量≥ 4 log10拷贝/ml ；b=ALT≥ 2 ×正常值上限（ULN）；c=ALT < 2 × ULN，但肝组织学显示Knodell HAI ≥ 4，或炎症坏死≥ G2，或纤维化≥S2。

2017年5月10日 · 恩替卡韦（ETV）为环戊酰鸟苷类似物，能抑制 HBV-DNA 多聚酶的启动、前基因组 mRNA 逆转录负链的形成及 HBV-DNA 正链的合成。 治疗 48 周时，HBeAg 阳性和阴性的 CHB 患者 HBV DNA 转阴率分别为 67%、90%。 是新版 EASL 指南明确推荐的一线抗病毒药物。 注意事项：（1）进食可导致药物吸收延迟，故应于餐前或餐后至少 2 小时服用。 （2）属于妊娠 C 级药物，服药期间出现意外妊娠时需换用 TDF 或 LdT。 替诺福韦酯（TDF），与恩替卡韦相 …

2016年7月1日 · Entecavir (ETV) is a potent viral replication inhibitor for chronic hepatitis B (CHB) patients. To investigate the efficacy of ETV in Chinese nucleos (t)ide (NA)-experienced CHB patients....

The current meta-analysis reached the following results: For both group A and group B, ETV monotherapy was more effective in improving the rate of undetectable HBV DNA than ETV-based combination therapy.

Results: We included randomized clinical trials (RCTs) and cohorts involving Group A: nucleos (t)ide-naive patients (four RCTs, n = 719 patients), Group B: nucleos (t)ide-resistant patients (four cohorts, n = 196 patients), and Group C: entecavir-treated patients with undetectable hepatitis B virus DNA (two RCTs and two cohorts, n = 297).

The objective of this study was to evaluate the effectiveness and safety of entecavir (ETV) and interferon (IFN) combination therapy in the treatment of chronic hepatitis B (CHB) mono-infection via a meta-analysis of randomized controlled trials ...

2017年3月9日 · This study was aimed to compare the long-term efficacy between them in treatment-naïve chronic hepatitis B (CHB). Out of 345 CHB patients who received first line therapy with ETV (n = 200) or TDF (n = 145) in a cohort, 210 patients were analyzed using propensity score matching, at a ratio of 1:1.

2018年8月21日 · Entecavir (ETV) is a first‐line therapy for chronic hepatitis B virus (HBV), demonstrating potent suppression of HBV DNA and a high barrier to viral resistance.