JNK，（c-Jun氨基末端激酶，c-Jun N-terminal kinase）又被称为应激活化蛋白激酶(stress-activated protein kinase, SAPK)，是哺乳类细胞中MAPK（mitogen-activated protein kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。

JNK 也称作 SAPKs（stress-activated protein kinases，应激激活的蛋白激酶），主要包括 JNK1（SAPKα，MAPK8）、JNK2（SAPKβ，MAPK9）、JNK3（SAPKγ，MAPK10）[1,3,5]。 JNK1、JNK2 在组织中广泛表达，而 JNK3 仅在脑、心和睾丸中表达 [2,5]。 JNK 磷酸化激活后可以作用下游多种转录因子（例如：Jun、Elk-1、Ets2等）与激酶（主要是MNK），产生促进生长、分化、存活、凋亡等多种生理效应 [1]。 活化的 JNK 能够磷酸化 c-Jun，其磷酸化位点位于 c …

In B-cells, JNK/c-Jun is activated by CD154-induced CD40 internalization in a JIP-dependent manner and regulates memory B-cell development . As a critical regulator of immune cell differentiation and activation, JNK is implicated in many immune-related skin disorders.

JNK是促分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)超家族成员之一。此外，由于JNK可被多种细胞外应激信号激活，其也被称为应激活化蛋白激酶(stress-activated MAP kinase，SAPK)。JNK家族共有三个JNK基因：JNK1、JNK2和JNK3，它们通过剪接产生异构体JNK1、JNK2和JNK3。

2007年4月1日 · JNK can activate the mitochondrial apoptotic pathway, can phosphorylate and activate several pro-apoptotic members of the Bcl2-related protein family, and can also phosphorylate and inhibit several anti-apoptotic members of the Bcl2-related protein family.

2005年8月15日 · Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family.

2010年12月2日 · 研究发现，用紫外线照射细胞后，一种蛋白激酶能够磷酸化f―jun，其磷酸化位点位于c―jun氨 基末端 活性区Set63和Ser73，该蛋白激酶被称为c―jun氨基末端激酶 (c―jun N―terminal kinase，JNK)。 JNK原来被称为应激激活的蛋白激酶 (SAPK)。 与其他MAPK一样，当酪氨酸和苏氨酸残基发生磷酸化后，JNK／SAPK也可被激活。 JNK可以受各种各样的细胞外刺激而激活，这些刺激包括生长因子、细胞因子和细胞应激。 细胞应激又包括热休克、脂多 …

Urolithin B 是 Ellagitannins 的肠道微生物代谢产物之一，具有抗炎和抗氧化作用。Urolithin B 通过降低 IκBα 的磷酸化和降解来抑制 NF-κB 活性。Urolithin B 抑制 JNK、ERK 和 Akt 的磷酸化，增强 AMPK 的磷酸化。Urolithin B 也是骨骼肌质量的调节因子。

2000年4月15日 · As its full name suggests, Jun N-terminal kinase (JNK, pronounced ‘junk’) is an enzyme that phosphorylates the amino-terminal domain of the Jun transcription factors. JNK is a serine/threonine kinase, a member of the extensive family of MAP kinase proteins critical for signal transduction pathways.

2011年6月1日 · However, the question of how the two JNK activators, MKK4 and MKK7 transfer a diversity of signals and contribute to distinct JNK effects has hardly been considered. Therefore, this review focuses on the importance of MKK4 and MKK7 within the JNK cascade.