Turning to APC function, we highlight the roles of B cells as thymic APC, as APC for T follicular helper (T FH), as APC for CD4 memory T cells and as presenters of idiotypic BCR …

Taken together, these data suggest that activated B cells within TLS may act as APCs and elicit a recall response among T cells that were primed in lymph nodes, promoting their survival and …

Definition of APC: Any cell that can process and present antigenic peptides in association with class II MHC molecules and deliver a co-stimulatory signal necessary for T cell activation. This …

2013年6月25日 · In this Review, we discuss membrane trafficking and the associated molecular mechanisms that are involved in antigen extraction and processing at the B cell synapse, and …

Studies show that CD154- or mitogen-activated B cells function as effective antigen presenting cells (APC) to induce T-cell activation (6, 7), while resting B cells are tolerogenic (8).

2021年6月1日 · In addition to their role as antibody producing cells, B cells make a critical contribution to adaptive immune responses by functioning as professional antigen-presenting …

2022年9月8日 · The function of B cells as professional antigen presenting cells (APCs) to activate T cells has been largely understudied. This, however, requires attention as several recent …

2005年12月1日 · When presenting antigen in a resting state, B cells can induce T cell tolerance. On the other hand, activation by antigen and T cell help converts them into APC capable of …

2021年7月1日 · B lymphocytes have multiple functions central to humoral immunity, including Ag presentation to T cells, cytokine secretion, and differentiation into Ab-secreting plasma cells. In …

Presentation of intact antigen as a transmembrane protein triggers formation of a BCR-dependent immunological synapse (B synapse). The B cell synapse extracts intact antigen from the APC …