Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. [1][2][3] Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. [4]

2014年6月20日 · Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the development of B cell memory. Historically, FDCs have been characterized as...

生发中心（germinal center, GC）是抗原特异性B细胞激活后大量增殖形成的结构，其主要组成成分是B细胞，还包括滤泡协助性T细胞（follicular helper T, Tfh）、滤泡树突状细胞（follicular dendritic cell，FDC）和巨噬细胞。

进入以后，B细胞继续受到 滤泡树突状细胞 （follicular dendritic cells, FDC）分泌的CXCL13（也是一种chemokine，能被B细胞表面受体CXCR5识别）影响来到初级淋巴滤泡（primary lymphoid follicle）中。

Follicular dendritic cells (FDCs) are stromal cells residing in primary follicles and in germinal centers of secondary and tertiary lymphoid organs (SLOs and TLOs). There, they play a crucial role in B-cell activation and affinity maturation of ...

2024年3月26日 · In recent years, it has become increasingly clear that GC reactions are in large part orchestrated by follicular dendritic cells (FDCs), which present antigen, deliver stimulatory cytokines to B cells, and provide structural support. 10,11 FDCs have the unique ability to retain and present complement opsonized immune complexes (ICs) for extended...

Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune complexes and more recent findings indicate that they are a source of B cell attractants and trophic factors. New imaging studies have shown that B cells closely associate with their dendritic processes during migration.

2019年11月26日 · Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells. While essential for germinal center (GC) responses, their exact role during GC B cell selection remains unknown.

The two main cell types implicated in native antigen presentation to B cells are follicular dendritic cells (FDC), which reside in B cell follicles, and CD169 + macrophages, which line the antigen-exposed surfaces of these follicles in both the lymph nodes and the spleen.

2013年6月1日 · The FDC function is to bind and retain antigens by linking to complement and immune complexes and then present these antigens to germinal center B cells that start the secondary immune response. FDCs aid in the rescue of bound B cells from apoptosis, and induce the differentiation of B cells into long-term memory B cell clones or plasma cells.