B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for the study of metastasis and solid tumor formation, and were one of the first effective murine tools for metastasis research.

In B16 melanoma cancer cell lines, cells with higher metastatic potential were more deformable at the whole-cell level with undeveloped actin filament structure, even when highly deformed. These results imply that invasive cancer cells may gain the ability to inhibit actin filament development.

B16 is the skin cancer (melanoma) cell line of murine origin. This cell line is an effective in vitro model for studying human skin cancers. It is frequently used to investigate solid tumour formation and metastasis of cancer cells. This article will assist you in understanding the basics of the B16 melanoma cell line.

2021年10月19日 · Upon subcutaneous injection, B16 will form a palpable tumor in 5 to 10 days and grow to a 1 × 1 × 1–cm tumor in 14 to 21 days. When allowed to grow larger, the tumors often become necrotic in the center and begin to ulcerate or bleed; it is advisable to sacrifice the mice before this point.

易于成长：b16细胞系很容易在研究实验室中培养。它被广泛用于研究癌症细胞生物学、信号通路等。 快速增长： b16黑色素瘤细胞 系表现出高增殖率，使其适合研究细胞分裂和生长过程。 致瘤性：b16是一种具有侵袭、迁移和增殖等肿瘤样特性的致瘤细胞系。

2021年5月27日 · In B16 melanoma cancer cell lines, cells with higher metastatic potential were more deformable at the whole-cell level with undeveloped actin filament structure, even when highly deformed. These results imply that invasive cancer cells may gain the ability to inhibit actin filament development.

One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real practical interest. For this aim, modern ...

2025年3月17日 · 分析显示，B16、4T1、LLC1-sgLkb1模型在放免联合治疗后，上调最显著的主要是细胞外基质重塑相关通路，3个肿瘤模型共同上调的差异基因都主要表达于肿瘤相关成纤维细胞（Cancer-associated fibroblasts，CAFs）。

2025年1月16日 · To investigate brain tropism, we generated new variants of the B16 mouse melanoma model by serially passaging B16 cells through the brain of immune competent syngeneic C57BL/6 mice. Cells were injected into the right carotid artery and recovered from the brain after the mice had reached the study endpoint due to tumor burden, then expanded in ...

Cancer research: The B16-F10 cell line is a valuable model to study cancer cell processes, including proliferation, invasion, migration, and cell death or apoptosis. Besides, it helps researchers to gain insights into molecular mechanisms and …