B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for the study of metastasis and solid tumor formation, and were one of the first effective murine tools for metastasis research.

B16-F10 is a cell line exhibiting a morphology of spindle-shaped and epithelial-like cells that was isolated from skin tissue of a mouse with melanoma. Use these cells in your skin cancer research.

2021年10月19日 · As a model system, the authors used the spontaneous C57BL/6-derived B16 melanoma, a well established and widely used tumor model in which treatment is notoriously difficult.

The melanoma B16 cells grow as monolayers and exhibit epithelial-like and spindle-shaped cell morphology. The size of the B16 cell line is approximately 15.4 μm. There are distinct subclones of B16 cells, including B16GMCSF, B164A5, B16FLT3, and B16F10.

In B16 melanoma cancer cell lines, cells with higher metastatic potential were more deformable at the whole-cell level with undeveloped actin filament structure, even when highly deformed. These results imply that invasive cancer cells may gain the ability to inhibit actin filament development.

One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real practical interest.

B16-F10 is a subclone of the B16 tumour cell line derived from C57BL/6J mice skin tissue. Herein, B16F10 melanoma cells were developed after intravenously injecting the B16 line into immunocompromised or syngeneic mice.