"B27 disease" occurs in individuals who have ankylosing spondylitis (AS) or preankylosing spondylitis and/or uveitis and are also positive for HLA-B27. Molecular mimicry between the bowel microbe Klebsiella and the HLA-B27 molecule, as well as the spinal collagens types I, III, and IV, indicates a pathological mechanism involving autoimmunity.

HLA-B27 and Ankylosing Spondylitis. There are hundreds of HLA genes, each identified by a different number. One gene, HLA-B27, is strongly associated with a big family of rheumatic diseases called spondyloarthropathies. It includes: Axial spondyloarthritis; Axial psoriatic arthritis; Reactive arthritis

Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) [1] is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells.

2023年7月4日 · The human leukocyte antigens (HLA) are gene loci in the major histocompatibility complex class I of genes on chromosome 6, present on all nucleated cells. This activity reviews the varied presentations of HLA-B27 associated syndromes. Diverse disease presentations often require interprofessional approaches to care for patients with HLA-B27 ...

2018年6月5日 · During the course of a workup for possible autoimmune arthritis or autoimmune back disease, your rheumatologist may order something called a HLA-B27 test. So what does a positive HLA-B27 mean? HLA-B27 antigen. HLA-B27 is a genetic test. The majority of people who have a positive HLA-B27 are perfectly healthy.

2024年10月1日 · Approximately 50-75% of patients with spondylitis in association with inflammatory bowel disease have HLA-B27. In contrast, patients who develop sclerouveitis in the presence of inflammatory...

The distinction between the disease-associated and non-associated subtypes may give an insight into precisely how HLA-B27 contributes to pathogenesis in the seronegative spondarthritides, whilst some of the pathogenesis hypotheses may help to elucidate the mechanisms of disease susceptibility, initiation and progression.

HLA-B27 related diseases share many features with classic autoinflammatory diseases and mounting data suggests that autoinflammation is a key component of disease pathogenesis. However, ample data also exist to support the role of the adaptive immune system.

As already mentioned, one of the strongest genetic associations (OR=60) of any polygenic human disease is with HLA B27. 3 Genome wide association studies (GWAS) show that AS involves both the adaptive and innate immune systems, and that the IL-23 and TNF pathways are the major effector pathways involved. 28 29

A negative result means you don't have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis. If you are white, you are more likely to test positive for the HLA-B27 antigens.